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Conditional Loss Of Pten In Myogenic Progenitors Leads To Postnatal Skeletal Muscle Hypertrophy But Age-Dependent Exhaustion Of Satellite Cells, Feng Yue, Pengpeng Bi, Chao Wang, Jie Li, Xiaoqi Liu, Shihuan Kuang

Department of Animal Sciences Faculty Publications

Skeletal muscle stem cells (satellite cells [SCs]) are normally maintained in a quiescent (G0) state. Muscle injury not only activates SCs locally, but also alerts SCs in distant uninjured muscles via circulating fac- tors. The resulting GAlert SCs are adapted to regener- ative cues and regenerate injured muscles more effi- ciently, but whether they provide any long-term benefits to SCs is unknown. Here, we report that em- bryonic myogenic progenitors lacking the phospha- tase and tensin homolog (Pten) exhibit enhanced proliferation and differentiation, resulting in muscle hypertrophy but fewer SCs in adult muscles. Interest- ingly, Pten null SCs are predominantly …