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Synthesis And Biological Evaluation Of Novel Capacitative Calcium Entry Blockers, Thadigiri Celina Mala
Synthesis And Biological Evaluation Of Novel Capacitative Calcium Entry Blockers, Thadigiri Celina Mala
Chemistry & Biochemistry Theses & Dissertations
Studies have shown that 2-aminoethoxydiphenyl borate (2-APB) inhibits thrombin-mediated influx of Ca2 + through store-operated calcium channels in human platelets. Based on this molecule, two sets (boron analogues and the non-boron analogues) were synthesized and characterized by IR, NMR and CHN analysis and evaluated in human platelets to block thrombin-induced [Ca2+] elevation.
The synthesis of the non-boron compounds was performed in a simple one step process. According to the literature, some of these compounds were synthesized previously by a complicated two-step process.
All the compounds synthesized were tested for biological activity and the results showed that they …