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De Novo Protein Structure Modeling And Energy Function Design, Lin Chen
De Novo Protein Structure Modeling And Energy Function Design, Lin Chen
Computer Science Theses & Dissertations
The two major challenges in protein structure prediction problems are (1) the lack of an accurate energy function and (2) the lack of an efficient search algorithm. A protein energy function accurately describing the interaction between residues is able to supervise the optimization of a protein conformation, as well as select native or native-like structures from numerous possible conformations. An efficient search algorithm must be able to reduce a conformational space to a reasonable size without missing the native conformation. My PhD research studies focused on these two directions.
A protein energy function—the distance and orientation dependent energy function of …