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Full-Text Articles in Life Sciences

Complete Genome Sequence Of Listeria Monocytogenes Strain Dpc6895, A Serotype 1/2b Isolate From Bovine Raw Milk, Aidan Casey, Aidan Coffey, Et. Al. Jun 2015

Complete Genome Sequence Of Listeria Monocytogenes Strain Dpc6895, A Serotype 1/2b Isolate From Bovine Raw Milk, Aidan Casey, Aidan Coffey, Et. Al.

Department of Biological Sciences Publications

Listeria monocytogenes is a foodborne pathogen and is the causative agent of listeriosis among humans and animals. The draft genome sequence of L. monocytogenes DPC6895, a serotype 1/2b strain isolated from the raw milk of a cow with subclinical bovine mastitis, is reported.


Synthesis And Biological Evaluation Of N-Alkoxyphenyl-3-Hydroxynaphthalene-2-Carboxanilides, Eoghan Nevin, Aidan Coffey, Jim O'Mahony, Et. Al. May 2015

Synthesis And Biological Evaluation Of N-Alkoxyphenyl-3-Hydroxynaphthalene-2-Carboxanilides, Eoghan Nevin, Aidan Coffey, Jim O'Mahony, Et. Al.

Department of Biological Sciences Publications

A series of fifteen new N-alkoxyphenylanilides of 3-hydroxynaphthalene-2-carboxylic acid was prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistant S. aureus strains, Mycobacterium tuberculosis H37Ra and M. avium subsp. paratuberculosis. Some of the tested compounds showed antibacterial and antimycobacterial activity against the tested strains comparable with or higher than that of the standards ampicillin or rifampicin. 3-Hydroxy-N-(2-propoxyphenyl)naphthalene-2-carboxamide and N-[2-(but-2-yloxy)-phenyl]-3-hydroxynaphthalene-2-carboxamide had MIC = 12 µM against all methicillin-resistant S. aureus strains; thus their activity is 4-fold higher than that of ampicillin. The second mentioned compound as well as 3-hydroxy-N-[3-(prop-2-yloxy)phenyl]-naphthalene-2-carboxamide had MICs = …


Draft Genome Sequences Of Six Different Staphylococcus Epidermidis Clones, Isolated Individually From Preterm Neonates Presenting With Sepsis At Edinburgh's Royal Infirmary, Paul Walsh, M. Bekaert, J. Carroll, T. Manning, B. Kelly, A. O'Driscoll, X. Lu, C. Smith, P. Dickinson, K. Templeton, P. Ghazal, Roy D. Sleator May 2015

Draft Genome Sequences Of Six Different Staphylococcus Epidermidis Clones, Isolated Individually From Preterm Neonates Presenting With Sepsis At Edinburgh's Royal Infirmary, Paul Walsh, M. Bekaert, J. Carroll, T. Manning, B. Kelly, A. O'Driscoll, X. Lu, C. Smith, P. Dickinson, K. Templeton, P. Ghazal, Roy D. Sleator

Department of Biological Sciences Publications

Herein, we report the draft genome sequences of six individual Staphylococcus epidermidis clones, cultivated from blood taken from different preterm neonatal sepsis patients at the Royal Infirmary, Edinburgh, Scotland, United Kingdom.


Complete Genome Sequences Of Vb_Lmos_188 And Vb_Lmos_293, Two Bacteriophages With Specificity For Listeria Monocytogenes Strains Of Serotypes 4b And 4e, Aidan Casey, Aidan Coffey, Et. Al. Apr 2015

Complete Genome Sequences Of Vb_Lmos_188 And Vb_Lmos_293, Two Bacteriophages With Specificity For Listeria Monocytogenes Strains Of Serotypes 4b And 4e, Aidan Casey, Aidan Coffey, Et. Al.

Department of Biological Sciences Publications

Listeria monocytogenes is responsible for the rare disease listeriosis, which is associated with the consumption of contaminated food products. We report here the complete genome sequences of vB_LmoS_188 and vB_LmoS_293, phages isolated from environmental sources and that have host specificity for L. monocytogenes strains of the 4b and 4e serotypes.