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Generation And Partial Characterization Of Testes Specific Promotor Sequences In Zebrafish (Danio Rerio), Rohini Rajendran
Generation And Partial Characterization Of Testes Specific Promotor Sequences In Zebrafish (Danio Rerio), Rohini Rajendran
Theses, Dissertations and Culminating Projects
The cAMP response element modulator (CREM) regulates cAMP- responsive genes and is an important component of the cAMP mediated signal transduction in spermatogenesis. CREM has a regulatory relationship with Inducible cAMP early repressor (ICER) which acts as a tumor suppressor and is a dominant negative transcriptional repressor with gonadal specific properties. ICER is also known to moderate cAMP antiproliferative actions and has been targeted in the past for expression in the ovaries of transgenic mouse models to generate higher levels of ovulation. Earlier studies on mice lacking the CREM gene have shown severe impairment in spermatogenesis.
Enhanced Green Fluorescent Protein …