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Full-Text Articles in Life Sciences
Fluorescent Photoinduced Electron Transfer (Pet) Proton Sensors, Risper Nyabeta
Fluorescent Photoinduced Electron Transfer (Pet) Proton Sensors, Risper Nyabeta
Theses, Dissertations and Culminating Projects
Two new fluorescent photoinduced electron transfer (PET) proton sensors based on anthracene and pyrazoline chromophores have been prepared. The anthracene sensor was prepared through alkylation of 2-pyridylcarbinol with 9-chloromethylanthracene and the pyrazoline sensor was prepared through an aldol condensation of 4- carboxybenzaldehyde and acetylpyridine followed by reaction with phenylhydrazine. The fluorescence of these sensors is modulated by the initiation or quenching of a PET process between the chromophore and a receptor due to protonation. The synthesis, characterization and proton binding studies of the new sensors are reported in this thesis.
The Effects Of Testosterone On The Induction Of Experimental Autoimmune Thyroiditis In Sprague-Dawley Rats, Travis William Reed
The Effects Of Testosterone On The Induction Of Experimental Autoimmune Thyroiditis In Sprague-Dawley Rats, Travis William Reed
Theses, Dissertations and Culminating Projects
Experimental Autoimmune Thyroiditis (EAT) could not be induced in young, immature Sprague-Dawley rats (150-200g). EAT was successfully induced in the same group of animals when they weighed 400g. The animals developed the disease every time. Sexual immaturity or immaturity of the immune system may be responsible for these results (Fernandez, 2006). It has been proven that pharmacologic doses of testosterone have shown immunosuppressive effects on the severity of EAT in the PVG/c strain of rats (Ahmed et al, 1982). In this current thesis research, it appears that normal physiologic levels of testosterone have no effect on the development and severity …
A Population Genetic Study Of The Zostera Marina (Eelgrass) Ecotypes Of Barnegat Bay, New Jersey And Implications For Grass Bed Restoration, Stephanie Marie Smith
A Population Genetic Study Of The Zostera Marina (Eelgrass) Ecotypes Of Barnegat Bay, New Jersey And Implications For Grass Bed Restoration, Stephanie Marie Smith
Theses, Dissertations and Culminating Projects
Zostera marina is a species of seagrass widely found in the northern Atlantic and northern Pacific Oceans. It is primarily a cold-water adapted plant that is capable of both sexual and asexual reproduction. Zostera marina serves many ecological roles, including stabilizing sediments, reducing current velocity, preventing erosion and providing food and shelter to many organisms. Eelgrass populations have suffered numerous large-scale declines due to both natural as well as human-induced causes. Specifically within Bamegat Bay, New Jersey, the Z. marina populations have declined by over 62% within the past 20 years. Restoration efforts have had diverse growth and survival rates, …
An Analysis Of Enzymatic Activity In Truncated And Wild-Type Auxin Conjugate Hydrolases In Medicago Trunculata (Barrel Clover) And Implications In Structural Modeling, Scott Sigethy
Theses, Dissertations and Culminating Projects
Auxins are plant phytohormones that play an important part in plant growth and development. The level of active auxins in plants is regulated by enzymes known as hydrolases that release inactive bound forms of auxins, known as conjugates, as the active free form. We have previously isolated and enzymatically characterized the auxin conjugate hydrolase family from the model legume Medicago truncatula (barrel clover). In the process of cloning the cDNA for the genes MtIAR31, -32, -33, -34, and -36, we also cloned a truncated version of MtIAR33 (AMtIAR33) that apparently expresses an alternative hydrolase protein from a secondary, internal AUG …
Isolation, Characterization, And Degradation Of Bakuchiol From Psoralidium Tenuiflorum, Pei-Jan Hsu
Isolation, Characterization, And Degradation Of Bakuchiol From Psoralidium Tenuiflorum, Pei-Jan Hsu
Theses, Dissertations and Culminating Projects
Bioactivity guided fractionation of the EtOAc extract from Psoralidium tenuiflorum afforded the known compound bakuchiol as a racemic mixture. This compound was purified by liquid-liquid partitions and chromatographic techniques followed by characterization with ]H NMR, 13C NMR, and GCMS which agreed with previous literature. Previously, bakuchiol was reported from Psoralea corylirolia and Posoralea glandulosa in nature which are from the same family as P. tenuiflorum. This compound exhibited Staphylococcus epidermidis cytotoxicity.
Two Dimensional NMR (HHCOSY and HETCOR) of bakuchiol indicated a disagreement with the previously described NMR structural assignment; a reassignment is described herein.
Long-term storage followed by attempted reisolation …