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Full-Text Articles in Life Sciences
Chitosan-Cellulose Composite For Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability, And Biocompatibility, April Harkins, Simon Duri, Luther C. Kloth, Chieu D. Tran
Chitosan-Cellulose Composite For Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability, And Biocompatibility, April Harkins, Simon Duri, Luther C. Kloth, Chieu D. Tran
Clinical Lab Sciences Faculty Research and Publications
Chitosan (CS), a polysaccharide derived from chitin, the second most abundant polysaccharide, is widely used in the medical world because of its natural and nontoxic properties and its innate ability for antibacterial and hemostasis effects. In this study, the novel composites containing CS and cellulose (CEL) (i.e., [CEL + CS]), which we have previously synthesized using a green and totally recyclable method, were investigated for their antimicrobial activity, absorption of anticoagulated whole blood, anti-inflammatory activity through the reduction of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and the biocompatibility with human fibroblasts. The [CEL + CS] composites were found to …
Facile Synthesis, Characterization, And Antimicrobial Activity Of Cellulose-Chitosan-Hydroxyapatite Composite Material: A Potential Material For Bone Tissue Engineering, Tamutsiwa M. Mututuvari, April Harkins, Chieu D. Tran
Facile Synthesis, Characterization, And Antimicrobial Activity Of Cellulose-Chitosan-Hydroxyapatite Composite Material: A Potential Material For Bone Tissue Engineering, Tamutsiwa M. Mututuvari, April Harkins, Chieu D. Tran
Clinical Lab Sciences Faculty Research and Publications
Hydroxyapatite (HAp) is often used as a bone-implant material because it is biocompatible and osteoconductive. However, HAp possesses poor rheological properties and it is inactive against disease-causing microbes. To improve these properties, we developed a green method to synthesize multifunctional composites containing: (1) cellulose (CEL) to impart mechanical strength; (2) chitosan (CS) to induce antibacterial activity thereby maintaining a microbe-free wound site; and (3) HAp. In this method, CS and CEL were co-dissolved in an ionic liquid (IL) and then regenerated from water. HAp was subsequently formed in situ by alternately soaking [CEL+CS] composites in aqueous solutions of CaCl2 …