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Full-Text Articles in Life Sciences
Physiological And Morphological Correlates Of Presynaptic Inhibition In Primary Afferents Of The Lamprey Spinal Cord, I. V. Batueva, E. A. Tsvetkov, A. K. Sagatelyan, James T. Buchanan, N. Vesselkin, V. Adanina, E. I. Suderevskaya, J. -P Rio, J. Repérant
Physiological And Morphological Correlates Of Presynaptic Inhibition In Primary Afferents Of The Lamprey Spinal Cord, I. V. Batueva, E. A. Tsvetkov, A. K. Sagatelyan, James T. Buchanan, N. Vesselkin, V. Adanina, E. I. Suderevskaya, J. -P Rio, J. Repérant
Biological Sciences Faculty Research and Publications
Patch-clamp recordings in a whole-cell mode were performed on dorsal sensory cells enzymatically isolated from the spinal cord of two lamprey species, Ichthyomyzon unicuspis and Lampetra fluviatilis. The voltage-activated currents through calcium channels were analysed. GABA and the specific GABAB receptor agonist baclofen reduced the peak amplitude of inward Ba2+ current, as a robust alternate charge carrier through voltage-dependent Ca2+ channels. These effects were dose-dependent and reversible. GABAB receptor antagonists, 2-hydroxysaclofen and δ-amino-n-valeric acid, blocked the reduction of Ba2+ currents by GABA and baclofen, while bicuculline, a GABAA receptor antagonist, had no blocking …