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Therapeutic Peptide Sequences And Gatekeepers Loaded With Mesoporous Silica Nanoparticles, Dursitu Hassen
Therapeutic Peptide Sequences And Gatekeepers Loaded With Mesoporous Silica Nanoparticles, Dursitu Hassen
Kansas State University Undergraduate Research Conference
The research community is developing and looking into new ways of effectively delivering anti-cancer treatment. According to National Cancer Institute over 1.5 million new cases of cancer are predicted in the United States, just alone in 2018. The major hurdles that have been identified by scientists are finding mechanisms that assist in decreasing the side effects of cancer treatment and to increase the effectiveness of the drug. In our lab, a highly toxic peptide sequence, SA-K6L9-AS is encapsulated in MSNs (mesoporous silica nanoparticles) and capped with a gatekeeper. The function of a gatekeeper is preventing the …
Establishment Of 3-D Human Colorectal Cancer Spheroids, India Barnett
Establishment Of 3-D Human Colorectal Cancer Spheroids, India Barnett
Kansas State University Undergraduate Research Conference
Three-Dimensional (3D) cell culture plays an important role in cancer biology by providing a life-like microenvironment as a model for drug discovery and treatment. Hydrogels, like many other 3D scaffolds, demonstrate a unique property as matrices for 3D cell culture. The goal of this project is to establish a 3D cell culture for colorectal cancer and apply this 3D model to drug testing. Colorectal cancer is one of the most common cancers in the United States with an early detection rate of 39%. Previously, 2D cell culture of human colorectal cancer cells, SW480, was used to determine the efficacy of …