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Full-Text Articles in Life Sciences
Lifespan-Extending Caloric Restriction Or Mtor Inhibition Impair Adaptive Immunity Of Old Mice By Distinct Mechanisms, Emily L. Goldberg, Melissa J. Romero-Aleshire, Kristin R. Renkema, Melissa S. Ventevogel, Wade M. Chew, Jennifer L. Uhrlaub, Megan J. Smithey, Kirsten H. Limesand, Gregory D. Sempowski, Heddwen L. Brooks, Janko Nikolich-Zugich
Lifespan-Extending Caloric Restriction Or Mtor Inhibition Impair Adaptive Immunity Of Old Mice By Distinct Mechanisms, Emily L. Goldberg, Melissa J. Romero-Aleshire, Kristin R. Renkema, Melissa S. Ventevogel, Wade M. Chew, Jennifer L. Uhrlaub, Megan J. Smithey, Kirsten H. Limesand, Gregory D. Sempowski, Heddwen L. Brooks, Janko Nikolich-Zugich
Peer Reviewed Articles
Aging of the world population and a concomitant increase in age-related diseases and disabilities mandates the search for strategies to increase healthspan, the length of time an individual lives healthy and productively. Due to the age-related decline of the immune system, infectious diseases remain among the top 5–10 causes of mortality and morbidity in the elderly, and improving immune function during aging remains an important aspect of healthspan extension. Calorie restriction (CR) and more recently rapamycin (rapa) feeding have both been used to extend lifespan in mice. Preciously few studies have actually investigated the impact of each of these interventions …
Estrogens Stimulate Serotonin Neurons To Inhibit Binge-Like Eating In Mice, Xuehong Cao, Pingwen Xu, Mario G. Oyola, Yan Xia, Xiaofeng Yan, Kenji Saito, Fang Zou, Chunmei Wang, Yongjie Yang, Antentor Hinton Jr., Chunling Yan, Hongfang Ding, Liangru Zhu, Likai Yu, Bin Yang, Benjamin Feng, Deborah J. Clegg, Sohaib Khan, Richard Dimarchi, Shaila K. Mani, Qingchun Tong, Yong Xu
Estrogens Stimulate Serotonin Neurons To Inhibit Binge-Like Eating In Mice, Xuehong Cao, Pingwen Xu, Mario G. Oyola, Yan Xia, Xiaofeng Yan, Kenji Saito, Fang Zou, Chunmei Wang, Yongjie Yang, Antentor Hinton Jr., Chunling Yan, Hongfang Ding, Liangru Zhu, Likai Yu, Bin Yang, Benjamin Feng, Deborah J. Clegg, Sohaib Khan, Richard Dimarchi, Shaila K. Mani, Qingchun Tong, Yong Xu
Peer Reviewed Articles
Binge eating afflicts approximately 5% of US adults, though effective treatments are limited. Here, we showed that estrogen replacement substantially suppresses binge-like eating behavior in ovariectomized female mice. Estrogen-dependent inhibition of binge-like eating was blocked in female mice specifically lacking estrogen receptor-α (ERα) in serotonin (5-HT) neurons in the dorsal raphe nuclei (DRN). Administration of a recently developed glucagon-like peptide-1–estrogen (GLP-1–estrogen) conjugate designed to deliver estrogen to GLP1 receptor–enhanced regions effectively targeted bioactive estrogens to the DRN and substantially suppressed binge-like eating in ovariectomized female mice. Administration of GLP-1 alone reduced binge-like eating, but not to the same extent as …
Post-Transplant High-Dose Cyclophosphamide For The Prevention Of Graft-Versus-Host Disease, Ahmad Samer Al-Homsi, Tara S. Roy, Kelli Cole, Benjamin Feng, Ulrich Duffner
Post-Transplant High-Dose Cyclophosphamide For The Prevention Of Graft-Versus-Host Disease, Ahmad Samer Al-Homsi, Tara S. Roy, Kelli Cole, Benjamin Feng, Ulrich Duffner
Peer Reviewed Articles
Cyclophosphamide's lack of hematopoietic stem cell toxicity and its unique effects on the immune system have prompted several investigators to explore its potential for the prevention of graft-versus-host disease (GVHD). In haploidentical hematopoietic stem cell transplants, post-transplant cyclophosphamide together with standard prophylaxis reduces the incidence of GVHD to acceptable rates without the need for T cell depletion. In matched related and unrelated donor settings, cyclophosphamide alone has produced encouraging results. In particular, the low incidence of chronic GVHD is noteworthy. Here, we present a review of the current understanding of the mechanism of action of post-transplant cyclophosphamide and summarize the …