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Full-Text Articles in Life Sciences
The Effect Of Cytosine Methylation On The Structure And Geometry Of The Holliday Junction: The Structure Of D(Ccggtacm5 Cgg) At 1.5 Å Resolution, Jeff Vargason, P. Shing Ho
The Effect Of Cytosine Methylation On The Structure And Geometry Of The Holliday Junction: The Structure Of D(Ccggtacm5 Cgg) At 1.5 Å Resolution, Jeff Vargason, P. Shing Ho
Faculty Publications - Department of Biological & Molecular Science
No abstract provided.
Pka Phosphorylation Of Src Mediates Camp's Inhibition Of Cell Growth Via Rap1, John M. Schmitt, Philip J. S. Stork
Pka Phosphorylation Of Src Mediates Camp's Inhibition Of Cell Growth Via Rap1, John M. Schmitt, Philip J. S. Stork
Faculty Publications - Department of Biological & Molecular Science
In fibrolast cells, cAMP antagonizes growth factor activation of ERKs and cell growth via PKA and the small P protein Rap1. We demonstrate here that PKA's activation of Rap1 was mediated by the Rap1 guanine nucleotide exchange factor C3G, the adaptor Crk-L, the scaffold protein Cbl, and the tyrosine kinase Src. Src was required for cAMP activation of Rap1 and the inhibition of ERKs and cell growth. PKA activated Src both in vitro and in vivo by phosphorylation was required for cAMP's activation of Src and Rap1, as well as cAMP's inhibition of ERKs and cell proliferation. This study identifies …
Crosstalk Between Camp And Map Kinase Signaling In The Regulation Of Cell Proliferation, Philip J. S. Stork, John M. Schmitt
Crosstalk Between Camp And Map Kinase Signaling In The Regulation Of Cell Proliferation, Philip J. S. Stork, John M. Schmitt
Faculty Publications - Department of Biological & Molecular Science
Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent protein kinase PKA regulates cell growth by multiple mechanisms. A hallmark of cAMP is its ability to stimulate cell growth in many cell types while inhibiting cell growth in others. In this review, the cell type-specific effects of cAMP on the mitogen-activated protein (MAP) kinase (also called extracellular signal-regulated kinase, or ERK) cascade and cell proliferation are examined. Two basic themes are discussed. First, the capacity of cAMP for either positive or negative regulation of the ERK cascade accounts for many of the cell type-specific actions of cAMP on cell …
Ga And Gby Require Distinct Src-Dependent Pathways To Activate Rap1 And Ras, John M. Schmitt, Philip J. S. Stork
Ga And Gby Require Distinct Src-Dependent Pathways To Activate Rap1 And Ras, John M. Schmitt, Philip J. S. Stork
Faculty Publications - Department of Biological & Molecular Science
No abstract provided.
Activation Of Central Melanocortin Pathways By Fenfluramlne, Lora K. Heisler, Michael A. Cowley, Laurence H. Tecott, Wei Fan, Malcolm J. Low, James L. Smart, Marcelo Rubinstein, Jeffrey B. Tatro, Jacob N. Marcus, Henne Holstege, Charlotte E. Lee, Roger D. Cone, Joel K. Elmquist
Activation Of Central Melanocortin Pathways By Fenfluramlne, Lora K. Heisler, Michael A. Cowley, Laurence H. Tecott, Wei Fan, Malcolm J. Low, James L. Smart, Marcelo Rubinstein, Jeffrey B. Tatro, Jacob N. Marcus, Henne Holstege, Charlotte E. Lee, Roger D. Cone, Joel K. Elmquist
Faculty Publications - Department of Biological & Molecular Science
D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to …
A Complex, Cross-Taxon, Chemical Releaser Of Antipredator Behavior In Amphibians, Dale M. Madison, Aaron M. Sullivan, John C. Maerz, James H. Mcdarby, Jason R. Rohr
A Complex, Cross-Taxon, Chemical Releaser Of Antipredator Behavior In Amphibians, Dale M. Madison, Aaron M. Sullivan, John C. Maerz, James H. Mcdarby, Jason R. Rohr
Faculty Publications - Department of Biological & Molecular Science
Prey species show diverse antipredator responses to chemical cues signaling predation threat. Among terrestrial vertebrates, the red-backed salamander, Plethodon cinereus, is an important species in the study of these chemical defenses. During the day and early evening, this species avoids rinses from garter snakes, Thamnophis sirtalis, independent of snake diet, but late at night, avoids only those rinses from garter snakes that have recently eaten P. cinereus. We tested whether the selective, late-night response requires the ingestion or injury of salamanders. In three experiments, we tested P. cinereus for their responses to separate or combined rinses from salamanders (undisturbed, distressed, …
Sex Differences And Seasonal Trade-Offs In Response To Injured And Non-Injured Conspecifics In Red-Spotted Newts, Notophthalmus Viridescens, Jason R. Rohr, Dale M. Madison, Aaron M. Sullivan
Sex Differences And Seasonal Trade-Offs In Response To Injured And Non-Injured Conspecifics In Red-Spotted Newts, Notophthalmus Viridescens, Jason R. Rohr, Dale M. Madison, Aaron M. Sullivan
Faculty Publications - Department of Biological & Molecular Science
Injured prey often release alarm chemicals that induce antipredator behaviors in conspecifics. Injured or killed prey most likely release a wide array of chemicals in addition to alarm substances, such as sexual pheromones, which could enhance or compromise antipredator responses. Thus, damage-release cues provide an excellent opportunity to examine the influence of seasonally fluctuating sexual pheromones on antipredator behaviors. We used a series of laboratory and field experiments and meta-analysis to examine seasonal changes and sex differences in the response of red-spot-ted newts, Notophthalmus viridescens, to the odor of non-injured conspecifics and conspecific tissue extracts, the latter of which presumably …
The Ontogeny Of Chemically-Mediated Antipredator Behaviours In Newts (Notophthalmus Viridescens): Responses To Injured And Non-Injured Conspecifics, Aaron M. Sullivan, Jason R. Rohr, Dale M. Madison
The Ontogeny Of Chemically-Mediated Antipredator Behaviours In Newts (Notophthalmus Viridescens): Responses To Injured And Non-Injured Conspecifics, Aaron M. Sullivan, Jason R. Rohr, Dale M. Madison
Faculty Publications - Department of Biological & Molecular Science
Responses to alarm chemicals from injured prey may influence predation risk and foraging success of receivers and senders, while learning can influence the strength of these responses. Thus, it is important to know when in ontogeny prey produce and detect alarm substances and how learning shapes their response, but surprisingly little is known about either of these topics. We assessed when in the life of red-spotted newts, Notophthalmus viridescens, alarm chemicals are produced and detected by comparing adult versus eft (terrestrial juveniles) and larval responses to rinses and tissue extracts from individuals in each life-history stage. To evaluate the influence …