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Indole Alkaloids From Fischerella Inhibit Vertebrate Development In The Zebrafish (Danio Rerio) Embryo Model, Katherine Walton, Miroslav Gantar, Patrick D.L. Gibbs, Michael C. Schmale, John P. Berry
Indole Alkaloids From Fischerella Inhibit Vertebrate Development In The Zebrafish (Danio Rerio) Embryo Model, Katherine Walton, Miroslav Gantar, Patrick D.L. Gibbs, Michael C. Schmale, John P. Berry
Department of Chemistry and Biochemistry
Cyanobacteria are recognized producers of toxic or otherwise bioactive metabolite associated, in particular, with so-called “harmful algal blooms” (HABs) and eutrophication of freshwater systems. In the present study, two apparently teratogenic indole alkaloids from a freshwater strain of the widespread cyanobacterial genus, Fischerella (Stigonemataceae), were isolated by bioassay-guided fractionation, specifically using the zebrafish (Danio rerio) embryo, as a model of vertebrate development. The two alkaloids include the previously known 12-epi-hapalindole H isonitrile (1), and a new nitrile-containing variant, 12-epi-ambiguine B nitrile (2). Although both compounds were toxic to developing embryos, the former compound was shown to be relatively more potent, …