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Genetic Markers In Circulating Tumour Cells As A Measure Of The Metastatic Propensity Of Uveal Melanoma, Aaron Beasley
Genetic Markers In Circulating Tumour Cells As A Measure Of The Metastatic Propensity Of Uveal Melanoma, Aaron Beasley
Theses: Doctorates and Masters
Background: Uveal melanoma (UM) is an extremely aggressive disease with approximately 50% of patients developing incurable metastatic disease. Therefore, accurate prognosis of a patient is necessary for closer follow up and the earlier implementation of systemic adjuvant therapies in those most likely to develop metastatic disease. Fortunately, UM can be classified into two distinct molecular classes based on clinically validated gene expression profiling, chromosomal aberrations and specific driver mutations, which accurately predict the metastatic propensity of the primary tumour. However, genetic testing currently requires biopsy of the eye which can lead to serious complications including permanent blindness. Therefore, an alternative …