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Associations Of Circulating Very-Long-Chain Saturated Fatty Acids And Incident Type 2 Diabetes: A Pooled Analysis Of Prospective Cohort Studies, Amanda M. Fretts, Fumiaki Imamura, Matti Marklund, Renata Micha, Jason H. Y. Wu, Rachel A. Murphy, Kuo-Liong Chien, Barbara Mcknight, Nathan L. Tintle, Nita G. Forouhi, Waqas T. Qureshi, Jyrki K. Virtanen, Kerry Wong, Alexis C. Wood, Maria Lankinen, Kalina Rajaobelina, Tamara B. Harris, Luc Djousse, Bill Harris, Nick J. Wareham, Lyn M. Steffen, Markku Laakso, Jenna Veenstra, Cecilia Samieri, Ingeborg A. Brouwer, Chaoyu Ian Yu, Albert Koulman, Brian T. Steffen, Catherine Helmer, Nona Sotoodehnia, David Siscovick, Vilmunder Gudnason, Interact Consortium, Lynne Wagenknecht, Sari Voutilainen, Michael Y. Tsai, Matti Uusitupa, Anya Kalsbeek, Claudine Berr, Dariush Mozaffarian, Rozenn N. Lemaitre

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Background: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed.

Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies.

Methods: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. …