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An Investigation Into Splicing Variation And Expression Patterns Of Insulin-Like Peptide 4 (Ilp4) Within The Drosophila Genus, Zachary C. Griffith
An Investigation Into Splicing Variation And Expression Patterns Of Insulin-Like Peptide 4 (Ilp4) Within The Drosophila Genus, Zachary C. Griffith
Theses and Dissertations
The insulin-signaling pathway plays a crucial role in regulating metabolic homeostasis in both humans and insects. Dysregulation or mutation within this pathway can lead to various diseases, such as diabetes mellitus and insulin resistance. The insulin-like peptide 4 (ILP4) in Drosophila is an interesting subject for study due to its similarity to mammalian insulin and its role in regulating sugar metabolism. In this study, we investigate a novel splicing variation within the Drosophila takahashii Insulin-Like Peptide 4 (ILP4) gene. Our investigation identified a splicing variation found in four Drosophila species that introduces an additional codon in one isoform, resulting in …