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Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
An Investigation Of Bag3 Knockdown And Its Effects On The Cytotoxicity Of Laromustine, Colin Sheehan
An Investigation Of Bag3 Knockdown And Its Effects On The Cytotoxicity Of Laromustine, Colin Sheehan
Honors Theses
Laromustine is a sulfonylhydrazine anticancer prodrug whose main cytotoxic arises from its ability to interfere with DNA replication of dividing cells. Multiple studies have suggested that Laromustine induces a form of cell death known as apoptosis. In a previous study investigating the mechanism of apoptosis, bcl2-associated athanogene 3 (BAG3) demonstrated significant upregulation in the presence of Laromustine. Given its anticancer ability, we selected BAG3 as a target for further investigation. BAG3 knockdown through transient shRNA transfections was performed in U138 glioblastoma multiforme cells and verified using qRT-PCR analysis. Finally, cell death assays were used to assess Laromustine’s cytotoxic effect on …
School Gardens: Cultivating A Child’S Nutritional Habits, Environmental Knowledge, And Sustainability Practices, Jeffrey Meltzer
School Gardens: Cultivating A Child’S Nutritional Habits, Environmental Knowledge, And Sustainability Practices, Jeffrey Meltzer
Honors Theses
School gardens have existed since the late nineteenth century and today are becoming increasingly popular in many parts of the world, including where I studied in Maine and Australia (AUS). Multiple organizations support school gardens in Maine, including the Maine School Garden Network, which has over 125 registered school gardens. In AUS, the Stephanie Alexander Kitchen Garden Foundation primarily supports the school garden movement and has over 800 registered school gardens. While many researchers have studied school gardens, few have compared two countries, focused on environmental sustainability, or investigated Maine in particular. This thesis combines information from literature reviews, and …
Mathematical Modeling Of Emiliania Huxleyi And A Host-Specific Virus, Julia Middleton
Mathematical Modeling Of Emiliania Huxleyi And A Host-Specific Virus, Julia Middleton
Honors Theses
The world’s oceans provide the basis for life on the planet. One microscopic algae, the coccolithophores, and Emiliania huxleyi in particular, is a major source of carbon drawdown in the context of the global carbon cycle and account for a significant amount of the primary production in oceanic ecosystems. We know that the oceans are packed with marine viruses and they have an important role in the rise and fall of plankton populations but current mathematical models do not accurately account for virus-host interactions when predicting plankton blooms. Therefore I am using model optimization and comparison techniques to evaluate current …