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2007 Scholars And Artists Bibliography, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library, Joanne E. Goodell Ph.D.

Scholars and Artists Bibliographies

This bibliography was created for the annual Friends of the Michael Schwartz Library Scholars and Artists Reception, recognizing scholarly and creative achievements of Cleveland State University faculty, staff and emeriti. Dr. Joanne Goodell was the guest speaker.

Optimization Of Non-Natural Nucleotides For Selective Incorporation Opposite Damaged Dna, Diana Vineyard, Xuemei Zhang, Alison Donnelley, Irene Lee, Anthony J. Berdis

Chemistry Faculty Publications

The promutagenic process known as translesion DNA synthesis reflects the ability of a DNA polymerase to misinsert a nucleotide opposite a damaged DNA template. To study the underlying mechanism of nucleotide selection during this process, we quantified the incorporation of various non-natural nucleotide analogs opposite an abasic site, a non-templating DNA lesion. Our kinetic studies using the bacteriophage T4 DNA polymerase reveal that the π-electron surface area of the incoming nucleotide substantially contributes to the efficiency of incorporation opposite an abasic site. A remaining question is whether the selective insertion of these non-hydrogen-bonding analogs can be achieved through optimization of …

The Use Of Non-Natural Nucleotides To Probe Template-Independent Dna Synthesis, Anthony J. Berdis, David Mccutcheon

Chemistry Faculty Publications

The vast majority of DNA polymerases use the complementary templating strand of DNA to guide each nucleotide incorporation. There are instances, however, in which polymerases can efficiently incorporate nucleotides in the absence of templating information. This process, known as translesion DNA synthesis, can alter the proper genetic code of an organism. To further elucidate the mechanism of template-independent DNA synthesis, we monitored the incorporation of various nucleotides at the “blunt-end” of duplex DNA by the high-fidelity bacteriophage T4 DNA polymerase. Although natural nucleotides are not incorporated at the blunt-end, a limited subset of non-natural indolyl analogues containing extensive π-electron surface …

The Effect Of Dispersal Ability In Winter And Summer Stoneflies On Their Genetic Differentiation, Alison L. Yasick, Robert A. Krebs, Julie A. Wolin

Biological, Geological, and Environmental Faculty Publications

1. Plecopteran species disperse less than most other aquatic insects. Within stoneflies, members of different families vary in the degree of wing morphology and season of adult emergence.

2.  Dispersal limitations were tested to determine if there were increased differences among the nearby, Chagrin and Grand River populations in north-eastern Ohio, by comparing genetic variation within the 16s rRNA region of mitochondrial DNA in two stoneflies. Allocapnia recta emerges in winter and often has rudimentary wings, and Leuctra tenuis emerges in summer with fully developed wings.

3. There was significant genetic variability between the samples of A. recta from two …

Changes In Major Element Hydrochemistry Of The Pecos River In The American Southwest Since 1935, Fasong Yuan, Seiichi Miyamoto, Shilpa Anand

Biological, Geological, and Environmental Faculty Publications

The Pecos River, situated in eastern New Mexico and western Texas, receives water from a drainage area of 91 000 km². There are primarily two major water inputs, namely snowmelt from winter storms in the headwater region of the southern Rocky Mountains and runoff from warm-season monsoonal rainfall in the lower valley. The Pecos River suffers from high levels of total dissolved solids (TDS >5000 mg L⁻¹) under normal flow conditions. This not only poses serious problems for agricultural irrigation and safe drinking water supply, but also results in a permanent loss of biodiversity. This study …

Assessing Causes Of Change In The Freshwater Mussels (Bivalvia: Unionidae) In The Black River, Ohio, Mark S. Lyons, Robert A. Krebs, Jeremy P. Holt, Louie J. Rundo, W. Zawiski

Biological, Geological, and Environmental Faculty Publications

Habitat destruction is believed to be the number one cause of the decline in unionid mussels. Around the world, cities, towns and agriculture alter the structure of watersheds, and the Black River in Ohio may be a typical example. We investigated the diversity and abundance of unionid mussels in this watershed and compared results to urbanization locations, to site-specific appearance of the habitat and to a 1997 fish survey, as host species are another factor important to the distribution of unionid mussels. Although shells were found for 21 species, only 11 of these species were found alive. Seven of the …