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Sequence Profile Of The Parallel Β Helix In The Pectate Lyase Superfamily, Susan Heffron, Gregory R. Moe, Volker Sieber, Jerome Mengaud, Pascale Cossart, Jacqueline Vitali, Frances Jumak

Physics Faculty Publications

The parallel β helix structure found in the pectatelyasesuperfamily has been analyzed in detail. A comparative analysis of known structures has revealed a unique sequenceprofile, with a strong positional preference for specific amino acids oriented toward the interior of the parallel β helix. Using the unique sequenceprofile, search patterns have been constructed and applied to the sequence databases to identify a subset of proteins that are likely to fold into the parallel β helix. Of the 19 families identified, 39% are known to be carbohydrate-binding proteins, and 50% belong to a broad category of proteins with sequences containing leucine-rich repeats …