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Full-Text Articles in Life Sciences
The Role Of Pitx Proteins In Early Xenopus Development, Ye Jin
The Role Of Pitx Proteins In Early Xenopus Development, Ye Jin
Dissertations, Theses, and Capstone Projects
Embryos of the African clawed frog Xenopus laevis are widely used for the study of early vertebrate development. The cement gland, which secrets mucus to help tadpoles attach to solid supports and live in relative safety, has long been used as a model to study the interplay between cell signaling pathways and transcription factors. It has been proposed that an intermediate level of Bone Morphogenetic Protein (BMP) signaling is essential for cement gland formation. In addition, several transcription factors have been linked to cement gland development. Among them, the homeodomain proteins Pitx1 and the closely related Pitx2c can generate ectopic …
Body Size Regulation Via Bmp Signaling In Caenorhabditis Elegans, Uday Madaan
Body Size Regulation Via Bmp Signaling In Caenorhabditis Elegans, Uday Madaan
Dissertations, Theses, and Capstone Projects
The body size of an organism can be a crucial determinant of access to nutrition, reproductive success and overall survival in the wild. However, how body size of an individual is determined is incompletely understood. Body size is a complex trait determined by multiple pathways and genes, making it difficult to understand the role of individual genes and pathways in determining overall size. In Caenorhabditis elegans, a homolog of Bone Morphogenetic Proteins (BMP) is a major regulator of body size; functional loss of DBL-1 leads to a small body size. Due to a drastic change in body size in dbl-1 …