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Full-Text Articles in Life Sciences

The Role Of Glutamate Neurotransmission In The Ventral Tegmental Area In The Expression Of Conditioned Approach Learning, Priscila Hachimine-Merli Sep 2017

The Role Of Glutamate Neurotransmission In The Ventral Tegmental Area In The Expression Of Conditioned Approach Learning, Priscila Hachimine-Merli

Dissertations, Theses, and Capstone Projects

Conditioned stimuli (CSs) come to function as CSs by acquiring the capacity to activate the same mesocorticolimbic dopamine (DA) neurons activated by primary rewards, producing conditioned activation of these neurons and their associated motivational states. This model stipulates that CSs activate mesocorticolimbic DA systems through the activation of glutamate receptors on DA neurons in the ventral tegmental area (VTA). We tested the hypothesis that glutamate receptor stimulation in the VTA is necessary for the expression of conditioned approach. Rats were tested in a conditioned approach protocol that consisted of 7 consecutive conditioning sessions (light presentations and food were paired), one …


The Nucleus Accumbens Core Dopamine D1 And Glutamate Ampa/Nmda Receptors Play A Transient Role In The Performance Of Pavlovian Approach Behavior, Veronica Dobrovitsky Sep 2017

The Nucleus Accumbens Core Dopamine D1 And Glutamate Ampa/Nmda Receptors Play A Transient Role In The Performance Of Pavlovian Approach Behavior, Veronica Dobrovitsky

Dissertations, Theses, and Capstone Projects

The role of the nucleus accumbens core (NAc core) continues to be redefined with newly acquired data on neurochemical mechanisms mediating the learning and performance of behavior. Previous empirical data showed that dopamine transmission at the D1 receptor (D1R) plays a transient role in the expression of learned Pavlovian approach behavior. Here we show that, prior to overtraining, dopamine activity at D1Rs specifically within the NAc core is critical for the performance of approach behavior elicited by the recently-acquired reward-paired cue. Blockade of D1Rs in the NAc core, but not the dorsomedial striatum or NAc shell, disrupted approach responses during …


Cognitive And Neurobiological Degeneration Of The Mental Lexicon In Primary Progressive Aphasia, Jet M. J. Vonk Sep 2017

Cognitive And Neurobiological Degeneration Of The Mental Lexicon In Primary Progressive Aphasia, Jet M. J. Vonk

Dissertations, Theses, and Capstone Projects

The ease with which we use the thousands of words in our vocabulary stands in stark contrast to our difficulty establishing how they are organized in our mind and brain. The breakdown of language due to cortical atrophy in primary progressive aphasia (PPA) creates conditions to study this organization at a cognitive and neurobiological level in that the three variants of this disease, namely non-fluent, logopenic, and semantic PPA, each bear their own signature of language-specific decline and cortical atrophy. As the impaired regions in each variant are linked to different lexical and semantic attributes of words, lexical decision performance …


Ecologies Of Embodied Minds Embedded: Radical Romantic Perspectives On Architectures Of Technology, Sharmaine Browne Sep 2017

Ecologies Of Embodied Minds Embedded: Radical Romantic Perspectives On Architectures Of Technology, Sharmaine Browne

Dissertations, Theses, and Capstone Projects

This dissertation explores Romantic responses to the role of architectural technologies in the development of material being, consciousness, and culture by applying a critical approach in which I combine radical embodied cognitive theory, ecocritical perspectives, and a phenomenological lens to select Romantic texts written from 1789 to 1884 in response to industrial modernity. While scholarship has thoroughly explored technology as a cultural force which inevitably shapes consciousness, I propose that a slight shift of emphasis from technology’s external influence to the material internalization of its influence allows for new perspectives—particularly in light of recent proposals in cognitive philosophy which assert …


Between Speech & Song: Clarifying The Sprechstimme Of Schoenberg's Pierrot Lunaire, Sara M. Paar Jun 2017

Between Speech & Song: Clarifying The Sprechstimme Of Schoenberg's Pierrot Lunaire, Sara M. Paar

Dissertations, Theses, and Capstone Projects

Since its creation, the technique of Sprechstimme has fascinated the audiences, performers, and composers of twentieth century music. What is it? How is it done? How should it be notated? At the fore of investigations into these questions has been Arnold Schoenberg’s Pierrot lunaire, the work in which Schoenberg debuted this new technique. Much has been written in regard to Schoenberg’s creation and use of Sprechstimme, as well as his own exploration of the speech/song continuum. Composers, conductors, and performers have all tried to make sense of the notation, instructions, and performances Schoenberg left behind. Despite this, confusion, …