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A Combinatorial Framework For Multiple Rna Interaction Prediction, Syed Ali Ahmed
A Combinatorial Framework For Multiple Rna Interaction Prediction, Syed Ali Ahmed
Dissertations, Theses, and Capstone Projects
The interaction of two RNA molecules involves a complex interplay between folding and binding that warranted recent developments in RNA-RNA interaction algorithms. However, biological mechanisms in which more than two RNAs take part in an interaction also exist.
A typical algorithmic approach to such problems is to find the minimum energy structure. Often the computationally optimal solution does not represent the biologically correct structure of the interaction. In addition, different biological structures may be observed, depending on several factors. Furthermore, scoring techniques often miss critical details about dependencies within different parts of the structure, which typically leads to lower scores …