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Full-Text Articles in Life Sciences
Sex Dependent Efficacy Of Taurine As A Treatment For Cocaine Drug Use: A Study Of Reward, Kevin Uribe
Sex Dependent Efficacy Of Taurine As A Treatment For Cocaine Drug Use: A Study Of Reward, Kevin Uribe
Dissertations and Theses
No abstract provided.
Acute Cocaine Differentially Induces Pka Phosphorylation Substrates In Male And Female Rats, Wei-Lun Sun, Luyi Zhou, Arbi Nazarian, Vanya Quinones-Jenab, Shirzad Jenab
Acute Cocaine Differentially Induces Pka Phosphorylation Substrates In Male And Female Rats, Wei-Lun Sun, Luyi Zhou, Arbi Nazarian, Vanya Quinones-Jenab, Shirzad Jenab
Publications and Research
Background: Sex differences in intracellular dopamine pathways may contribute to the known sex differences in psychomotor responses to cocaine and differential development of dependence. This study aimed to determine whether there are sex differences in the activation of the extracellular signal-regulated kinases (ERK1/2, or p44/p42 MAPK) and PKA phosphorylation-dependent substrates in the nucleus accumbens (NAcc) of male and female rats at baseline or after acute cocaine administration.
Methods: 60-day-old male and female Fischer rats were injected with saline or cocaine (30 mg/kg) and sacrificed 5, 15, 30, 45 or 90 minutes later. Total locomotor activity, Stereotypic, rearing, and ambulatory behaviors …