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D1 Dopamine Receptor Regulation Of Microtubule-Associated Protein-2 Phosphorylation In Developing Cerebral Cortical Neurons, Z.-M. Song, Ashiwel S. Undieh, Y.-Y. Fang, L. Zhang, S. Dracheva, S.C. Sealfon, M.S. Lidow

Publications and Research

This study addresses the hypothesis that the previously described capacity of D1 dopamine receptors (D1Rs) to regulate dendritic growth in developing cortical neurons may involve alterations in the phosphorylation state of microtubuleassociated protein-2 (MAP2). The changes in phosphorylation of this protein are known to affect its ability to stabilize the dendritic cytoskeleton. The study involved two systems: primary cultures of mouse cortical neurons grown in the presence of the D1R agonists, SKF82958 or A77636, and the cortex of neonatal transgenic mice overexpressing the D1A subtype of D1R. In both models, a decrease in dendritic extension corresponded with an elevation in …