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Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Optogenetic Induction Of Mitochondrial Oxidative Stress As A Potential Model To Study Non-Hereditary Als, Samia Alam
Optogenetic Induction Of Mitochondrial Oxidative Stress As A Potential Model To Study Non-Hereditary Als, Samia Alam
Student Theses and Dissertations
Mitochondrial dysfunction is a common denominator of neurodegenerative diseases, including hereditary and non-hereditary Amyotrophic Lateral Sclerosis (ALS). Ten percent of ALS cases are hereditary while a majority are sporadic, with no known hereditary link. For effective therapeutic approaches to be developed, there is a need for development of a sporadic animal model to better understand disease mechanism. In previous work, our laboratory developed an animal model (known as mitokiller flies) to study sporadic cases of ALS. The work reported in this honors thesis focuses on the use of optogenetics and electrophysiology recording to study the formation of excessive hydrogen peroxide …
Validating A New In Vivo Model To Study Als, Izabela J. Cimachowska
Validating A New In Vivo Model To Study Als, Izabela J. Cimachowska
Student Theses and Dissertations
Buildup of oxidative stress and mitochondrial dysfunction are well known characteristics of both sporadic and hereditary amyotrophic lateral sclerosis (ALS). While both forms of the disease seem to arise from common cellular dysfunction, the genetic disease is studied to a much greater extent. Engineering novel animal models of the sporadic form of the disease is crucial for development of druggable targets to treat ALS and understand the underlying mechanisms. Interestingly, accumulation of oxidative stress by exacerbated emission of reactive oxygen species (ROS) from presynaptic mitochondria is a hallmark of both hereditary and sporadic ALS. Previous work by our laboratory showed …
Mitochondrial Distribution Of Glycine Receptors In Motor Neuron Cell Lines, Katsiaryna Milashevich
Mitochondrial Distribution Of Glycine Receptors In Motor Neuron Cell Lines, Katsiaryna Milashevich
Student Theses and Dissertations
Although non-essential, glycine plays an important role in major metabolic reactions and is most known for its anti-inflammatory effects. An accumulation of contemporary research has shown that glycine is able to stabilize membrane potential using glycine receptors at the cellular level and to protect mitochondrial function directly, whether it is from inflammation, heavy metal poisoning, or ischemia-induced neuroinflammation. In this research, the existence of a hypothetical mitochondrial glycine receptor is examined. Immunofluorescence imaging was used to examine the presence of the glycine receptor subunits alpha 1 and alpha 2 in both non- differentiated and differentiated neuroblastoma cell lines. The preliminary …