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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
The Effect Of Stress Induced Premature Senescence On The Expression Of Heterogeneous Ribonucleoieoprotein, Yuriy Pechenyy
The Effect Of Stress Induced Premature Senescence On The Expression Of Heterogeneous Ribonucleoieoprotein, Yuriy Pechenyy
Dissertations and Theses
The role of heterogeneous nuclear ribonucleoproteins (hnRNP) in cellular senescence is yet to be defined. Cellular senescence is a terminal growth arrest in somatic cells. It is thought to be the consequence of telomeric shortening that acts as a DNA damage signal. Conversely, cells induced into premature senescence (SIPS) by oxidative stress, is independent of telomere attrition. Premature senescence has been proposed to be physiologically relevant as it can be induced by treatment with chemotherapeutic agents. In particular, we are studying the roles of hnRNP A1 and A2 in the maintenance of the senescence phenotype. hnRNPs are a family of …
Wnt Secretion Proteins Modulate Rankl-Induced Expression Of Aire In Thymic Epithelial Cells, Daniel Pollack
Wnt Secretion Proteins Modulate Rankl-Induced Expression Of Aire In Thymic Epithelial Cells, Daniel Pollack
Dissertations and Theses
Thymic epithelial cells (TEC) are essential for a proper adaptive immune response by regulating thymocyte development and establishing central tolerance. In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is thought to regulate cell survival, proliferation, and development although the direct molecular mechanisms in TECs have yet to be elucidated. The inducible inhibition of canonical Wnt signaling with Dkk1 leads to a rapid loss of TEC progenitors as well as a decline in mature Aire-expressing mTECs. Therefore, we explore the role of Wnt ligands potentially responsible for stimulating and/or regulating Wnt …
Evolution Of Floral Morphology And Symmetry In The Miconieae (Melastomataceae), Maria Gavrutenko
Evolution Of Floral Morphology And Symmetry In The Miconieae (Melastomataceae), Maria Gavrutenko
Dissertations and Theses
Analyses of evolution of floral morphology and symmetry broaden our understanding of the drivers of angiosperm diversification. Integrated within a flower, labile floral characters produce different phenotypes that promote variable interactions with pollinators. Thus, investigation of floral evolution may help infer potential historic transitions in pollinator modes and ecological pressures that generated present diversity. This study aims to explore morphological evolution of flowers in Miconieae, a species-rich Neotropical tribe within family Melastomataceae. Despite a constrained floral plan, Melastomataceae manage to achieve a variety of floral traits appealing to diverse pollinator types, with majority of the species requiring specialized “buzz pollination” …
Bone Marrow Derived Progenitor Cells And Their Contributions To The Thymic Stroma, Mohammed Hoque
Bone Marrow Derived Progenitor Cells And Their Contributions To The Thymic Stroma, Mohammed Hoque
Dissertations and Theses
The thymus serves as the primary lymphoid organ responsible for the development and selection of a self-tolerant T cell repertoire. In paradox to its critical functions for the adaptive immune response, the thymus undergoes a profound age associated decline beginning in early adult life resulting in significant decline in T-cell function.Thymic epithelial cells (TECs) are the most critical component of the thymic microenvironment and undergo rapid turn-over, so understanding the cellular mechanisms responsible for the maintenance of TEC number and organization will be critical in counteracting age associated involution, particularly in cancer patients, due to enhanced degeneration in response to …
A Role For A Predicted E. Coli Inner Membrane Lipoprotein In Cell Envelope Integrity, Charlie Chung
A Role For A Predicted E. Coli Inner Membrane Lipoprotein In Cell Envelope Integrity, Charlie Chung
Dissertations and Theses
One of the distinct characteristics of Gram-negative bacteria such as Escherichia coli is the possession of a double-membraned cell envelope. The outer membrane provides an additional layer of protection against hydrophobic molecules including antibiotics, contributing to the multidrug resistance crisis. The Gram-negative membrane is composed of phospholipids, glycolipids, and proteins. A large portion of the bacterial cellular proteome is composed of membrane proteins. Despite this, the functions of several membrane proteins are as yet undefined. Therefore, defining the physiological roles of uncharacterized membrane proteins is expected to provide us with insights into the biology of the Gram-negative cell envelope and …
Collective Chemotaxis Of Retinal Neural Cells From Drosophila Melanogaster In Controlled Microenvironments, Stephanie Zhang
Collective Chemotaxis Of Retinal Neural Cells From Drosophila Melanogaster In Controlled Microenvironments, Stephanie Zhang
Dissertations and Theses
More than 172 million people are influenced by a retinal disorder that stems from either age-related or developmental causes. Of those, 1.5 million people endure a developmental retinal disorder. In the developing retina, neural cells undergo a series of highly complicated differentiation and migration process. A main cause of these diseases is abnormal collective migration of neural progenitors hindering the retinogenesis process. However, our grasp of collective migration and signaling molecules, critical to the developing retina, is incompletely understood. Understanding the molecular mechanisms, such as the fibroblast growth factor pathway, that regulate glial and neuronal migration provides decisive insights in …
The Geographic Mosaic Of Wolbachia Infection In Melanitis Leda Butterfly Populations, Brandon E. Latorre
The Geographic Mosaic Of Wolbachia Infection In Melanitis Leda Butterfly Populations, Brandon E. Latorre
Dissertations and Theses
Insects are the most species-rich multicellular taxon on the planet, and it is estimated that more than half of all insect species are infected with the endosymbiont Wolbachia. This bacterium can manipulate the reproduction of its host and potentially affect host evolution. Most surveys investigating patterns of Wolbachia infection in nature sample limited numbers of individuals; population-level investigations into geographic differences in infection status that might affect host evolution are few. To investigate geographic variability among populations of a single species, we assayed 133 Melanitis leda butterflies (Lepidoptera: Nymphalidae: Satyrinae) for Wolbachia infection collected throughout its range in the …