Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Screen For Suppressors And Enhancers Of Excitotoxic Neurodegeneration, Anthony Omorodion Edokpolo
Screen For Suppressors And Enhancers Of Excitotoxic Neurodegeneration, Anthony Omorodion Edokpolo
Dissertations and Theses
Excitotoxicity is an important and frequently observed neurodegenerative process. Excitotoxicity mediates brain damage in a range of diseases and conditions including stroke, and is triggered by excessive stimulation of glutamatergic synapses. In spite of extensive studies, the molecular mechanisms involved in excitotoxicity following the over-activation of postsynaptic glutamate receptors are not well understood, and clinical trials based on our partial understanding of the process ended with disappointment. Genetic screens in simple animal models offer a powerful alternative approach, since screens are unbiased, analysis is facilitated by strong research tools, and cellular mechanisms are highly conserved through evolution. We produced a …
Synaptic Physiology Of Glutamate Clearance In The Nematode Caenorhabditis Elegans, Jenny (Chan Ying) Wong
Synaptic Physiology Of Glutamate Clearance In The Nematode Caenorhabditis Elegans, Jenny (Chan Ying) Wong
Dissertations and Theses
No abstract provided.