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Kshv Susceptibility And Transmission Within Tonsillar Specimens, Farizeh Aalam
Kshv Susceptibility And Transmission Within Tonsillar Specimens, Farizeh Aalam
Pharmaceutical Sciences (PhD) Dissertations
Despite nearly three decades of research, not much is known regarding the early stages of development for KSHV lymphoproliferative disorders, hindering our ability to develop prophylactic measures or effective treatments. This dissertation will focus on the host and viral factors influencing the magnitude and dynamics of KSHV infection in the human tonsil to pave the way for future interventions directed at limiting person-to-person transmission of KSHV.
To understand the contribution of host factors to KSHV susceptibility in B lymphocytes, we generated a library of 40 tonsillar specimens. Our results indicate that the immunological composition of tonsillar lymphocytes varies across our …