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Changes In Ventilatory Threshold At High Altitude: Effect Of Antioxidants, Andrew W. Subudi, Kevin A. Jacobs, Todd A. Hagobian, Jill A. Fattor, Stephen R. Muza, Charles S. Fulco, Allen Cymerman, Anne L. Friedlander
Changes In Ventilatory Threshold At High Altitude: Effect Of Antioxidants, Andrew W. Subudi, Kevin A. Jacobs, Todd A. Hagobian, Jill A. Fattor, Stephen R. Muza, Charles S. Fulco, Allen Cymerman, Anne L. Friedlander
Kinesiology and Public Health
Purpose: To investigate the effects of prolonged hypoxia and antioxidant supplementation on ventilatory threshold (VT) during high-altitude (HA) exposure (4300 m).
Methods: Sixteen physically fit males (25 ± 5 yr; 77.8 ± 8.5 kg) performed an incremental test to maximal exertion on a cycle ergometer at sea level (SL). Subjects were then matched on VO2peak, ventilatory chemosensitivity, and body mass and assigned to either a placebo (PL) or antioxidant (AO) supplement group in a randomized, double-blind manner. PL or AO (12 mg of β-carotene, 180 mg of α-tocopherol acetate, 500 mg of ascorbic acid, 100 μg of selenium, and 30 …
Cytokine Response At High Altitude: Effects Of Exercise And Antioxidants At 4300 M, Todd A. Hagobian, Kevin A. Jacobs, Andrew W. Subudhi, Jill A. Fattor, Paul B. Rock, Stephen R. Muza, Charles S. Fulco, Barry Braun, Ann Grediagin, Robert S. Mazzeo, Allen Cymerman, Anne L. Friedlander
Cytokine Response At High Altitude: Effects Of Exercise And Antioxidants At 4300 M, Todd A. Hagobian, Kevin A. Jacobs, Andrew W. Subudhi, Jill A. Fattor, Paul B. Rock, Stephen R. Muza, Charles S. Fulco, Barry Braun, Ann Grediagin, Robert S. Mazzeo, Allen Cymerman, Anne L. Friedlander
Kinesiology and Public Health
Purpose: This study tested the hypothesis that antioxidant supplementation would attenuate plasma cytokine (IL-6, tumor necrosis factor (TNF)-α), and C-reactive protein (CRP) concentrations at rest and in response to exercise at 4300-m elevation.
Methods: A total of 17 recreationally trained men were matched and assigned to an antioxidant (N = 9) or placebo (N = 8) group in a double-blinded fashion. At sea level (SL), energy expenditure was controlled and subjects were weight stable. Then, 3 wk before and throughout high altitude (HA), an antioxidant supplement (10,000 IU β-carotene, 200 IU α-tocopherol acetate, 250 mg ascorbic …