Life Sciences Commons^™

Analysis Of Copy Number Variation In The Abp Gene Regions Of Two House Mouse Subspecies Suggests Divergence During The Gene Family Expansions, Željka Pezer, Amanda G. Chung, Robert C. Karn, Christina M. Laukaitis

Scholarship and Professional Work - LAS

The Androgen-binding protein (Abp) gene region of the mouse genome contains 64 genes, some encoding pheromones that influence assortative mating between mice from different subspecies. Using CNVnator and quantitative PCR, we explored copy number variation in this gene family in natural populations of Mus musculus domesticus (Mmd) and Mus musculus musculus (Mmm), two subspecies of house mice that form a narrow hybrid zone in Central Europe. We found that copy number variation in the center of the Abp gene region is very common in wild Mmd, primarily representing the presence/absence of the final …