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Full-Text Articles in Life Sciences
Targeting Superoxide Dismutase-¬1 In Cancer, Laura Oh, Josh Andersen
Targeting Superoxide Dismutase-¬1 In Cancer, Laura Oh, Josh Andersen
Journal of Undergraduate Research
SOD1 is overexpressed in many cancers such as lung adenocarcinoma, non- small-cell lung cancer, and 70% of primary breast cancers. Traditionally, SOD1 is known as an antioxidant in the human body, but only 1% of SOD1 expressed in cells is necessary to keep superoxide radicals below cytotoxic levels, suggesting that SOD1 may have undiscovered functions. One of the known trademarks of cancer is the Warburg Effect defined by up-regulated glycolysis and down- regulated respiration. It is thought that this unique mode of metabolism promotes cancer cell growth. A recent study demonstrated that SOD1 functions to repress respiration through the casein …
Role Of The Viral Lana Protein In Human Cancers Caused By Kaposi’S Sarcoma-Associated Herpesvirus, Gregory Low, Brad Berges
Role Of The Viral Lana Protein In Human Cancers Caused By Kaposi’S Sarcoma-Associated Herpesvirus, Gregory Low, Brad Berges
Journal of Undergraduate Research
The purpose of our experiment was to ascertain the importance of the LANA protein encoded by the Kaposi’s Sarcoma-Associated Herpesvirus (KSHV). LANA is believed to be essential for the survival of KSHV in human cells. KSHV causes a variety of cancers including Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). These cancers most often appear in the immunocompromised and can be fatal. The mortality rate of PEL is ~60% after one year, KS 5-year mortality rate is ~30%, and MCD 5-year mortality rate is 35%. No known vaccine or anti-viral drug treatment is currently licensed for …