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Articles 1 - 17 of 17
Full-Text Articles in Life Sciences
Standardization Of A Latent Blood Visualizer Based Upon Dna Degradation, Kailey M. Van 'T Hoff
Standardization Of A Latent Blood Visualizer Based Upon Dna Degradation, Kailey M. Van 'T Hoff
Honors Projects
Latent blood visualizers have been used in forensic science since 1937 beginning with Luminol. These visualizers through different types of reactions react with trace amounts of blood that cannot be seen with the naked human eye. These different reactions produce color that can then be seen by examiners. The four types of latent blood visualizers that were compared is luminol, leuco crystal violet, fluorescein, and bluestar. Luminol and bluestar use chemiluminescence, fluorescein uses florescent, and leuco crystal violet uses oxidation to react with iron in hemoglobin. At crime scenes when blood is detected which includes with the blood visualizers the …
Screening Anti-Pd-L2 Peptides As Antitumor Ligands Using Phage Display, Chien Tran Phuoc
Screening Anti-Pd-L2 Peptides As Antitumor Ligands Using Phage Display, Chien Tran Phuoc
Honors Projects
Cancer still remains one of the top leading causes of death in America. Recently, programmed cell death protein 1 (PD-1) blockades have been demonstrated to be highly effective against various types of cancer. By blocking PD-1 from binding with their ligands (PD-L1 and PD-L2), the “off” signal to the immune system is inhibited, hence reinvigorating the immune cells to kill tumor cells. To date, despite PD-L1 and PD-L2 both interacting with PD-1, research efforts have only been focused on developing anti-PD-L1 inhibitors. Therefore, the work of this honor project has focused on finding anti-PD-L2 peptides by phage display, with the …
Eat Your Invasives: A Practical And Historical Analysis Of Foraging For Invasive Foods, Grace Hartman
Eat Your Invasives: A Practical And Historical Analysis Of Foraging For Invasive Foods, Grace Hartman
Honors Projects
This paper discusses both the historical and modern role of foraging and why people may decide to forage, as well as barriers new foragers may face and how they can be overcome. Furthermore, the paper discusses how foraging for invasive species can be used as a method of conservation and how simple foraging can be encouraged for this reason.
Autopsy V. Virtopsy: A New Approach For Postmortem Forensic Examination, Nicole Elaine Lawson
Autopsy V. Virtopsy: A New Approach For Postmortem Forensic Examination, Nicole Elaine Lawson
Honors Projects
Virtopsy as a potential new standard in forensic science investigation in the place of a conventional autopsy. In recent years there have been new advancements across the forensic field and in the scientific world as a whole. These advancements have changed many approaches bringing new capabilities and new challenges and pushback. This report takes a specific interest in the evolution of forensic autopsy. With improvements such as magnetic resonance imaging (MRI), computed tomography scan (CT), X-Rays, and other approaches a new term and technique have been coined Virtopsy. As this new potential approach has come to light the resistance against …
Multilingualism And Memory: Investigating Possible Differences In The Abilities Of Monolingual And Multilingual College Students, Clara E. Barned
Multilingualism And Memory: Investigating Possible Differences In The Abilities Of Monolingual And Multilingual College Students, Clara E. Barned
Honors Projects
This study investigated whether there is a difference in the memories of monolingual and multilingual undergraduate students using simple memorization tasks. There were 46 participants, 30 of which were monolingual (only knew one language) and 16 of which were multilingual (knew two or more languages). There was found to be no significant difference between the performance of the two groups, with the data generating a p-value of 0.557. This study further suggests related avenues of research and ways in which the study could be improved in the future.
The Relationship Between Circadian Rhythms And Neurodegenerative Disease, Christopher Simpson
The Relationship Between Circadian Rhythms And Neurodegenerative Disease, Christopher Simpson
Honors Projects
Neurodegenerative disease is a pervasive and insidious disease affecting a large proportion of the elderly population. Leading to the degeneration of neural tissue throughout the nervous system, it is a slow and progressive disorder. Because of its nature, it is possible that it has a connection to circadian rhythms. Circadian rhythms are the endogenous approximately 24-hour rhythms of the body commonly associated with the sleep-wake cycle, but they account for much more. This review aims to ascertain the relationship between the two by covering several facets of research pursued in the past five years. Beginning with establishing a basic understanding …
Use Of Intramodal Odor Cues In Shelter Recognition By An Amblypygid, Nathan Bostelman
Use Of Intramodal Odor Cues In Shelter Recognition By An Amblypygid, Nathan Bostelman
Honors Projects
Amblypygids are nocturnal arthropods which live in cluttered habitats and possess the ability to navigate home after displacements of up to ten meters. Homing amblypygids rely on olfactory and tactile information gathered by their antenniform legs to navigate successfully. Given that odor signals encountered in nature are complex and dynamic, navigation via olfaction presents unique challenges related to signal uncertainty. To understand how amblypygids perceive perceive complex odors and what they learn from them, individuals of the subtropical amblypygid P. marginemaculatus were trained to associate a blend of two odors with a shelter and tested on three treatments: the reinforced …
The Synthesis And Purification Methodology Of An Intermolecular Pyrophosphate Sensor: Applications For The Quantitative Polymerase Chain Reaction, Ethan Gevedon
Honors Projects
The optimized synthesis and purification methodology for an intermolecular pyrophosphate sensor scaffold molecule was performed: high performance liquid chromatography afforded the scaffold in excellent purity and yield. The applications of the sensor assembly in the quantitative polymerase chain reaction were discussed, and preliminary results show that
Aeromonas Phage Research And The Public Health Impact Of Antibiotics In Aquaculture Workers, Madelyn Merchant
Aeromonas Phage Research And The Public Health Impact Of Antibiotics In Aquaculture Workers, Madelyn Merchant
Honors Projects
One of the most common fish diseases in aquaculture is Aeromonas infection. The most common way to treat this infection is through antibiotics. The bacteria in the fish can become antibiotic-resistant and perpetuate the disease. The diseases in fish create a huge financial loss and the industry loses $6 billion per year due to diseases in fish. An alternative to antibiotics is bacteriophage which causes less environmental degradation and is better for human gut flora. In aquaculture there have been examples of aquaculture workers becoming sick from the water in aquaculture ponds as well as from people eating the fish. …
Diversity Of Bacteriophage In Burkholderia Species, Abigail Price
Diversity Of Bacteriophage In Burkholderia Species, Abigail Price
Honors Projects
Bacteriophages are viruses that infect and replicate within bacteria and offer the potential of a therapeutic alternative to chronic infections that do not respond to antibiotic-based therapies. B. vietnamiensis is one of a number of Burkholderia species involved with chronic drug resistant infections in the lungs of individuals with compromised respiratory systems, as found in those with chronic obstructive pulmonary disease and, most especially, are of particular significance in patients with cystic fibrosis. The diversity of the Burkholderia species is explored by using online databases and looking at bacteriophage or phage-encoding viruses found in B. vietnamiensis. The open reading frames …
Examining Bacteriophage Reliance On The Tola Protein Of Escherichia Coli, Ellen Davis
Examining Bacteriophage Reliance On The Tola Protein Of Escherichia Coli, Ellen Davis
Honors Projects
With the ever-growing crisis of antibiotic resistant bacteria, bacteriophage provide an important potential alternative therapy to treat infections when antibiotics are ineffective. For this reason, it is important to understand the mechanisms bacteriophage use to enter their bacterial host cell. The cellular envelope of the gram-negative bacterium E. coli contains a protein system known as Tol-Pal, which utilizes energy from the Proton Motive Force to carry out several cellular functions, including some associated with cellular division and outer-membrane stability. Certain bacteriophage take advantage of the energy produced by this system to cross the bacterial cell membrane. One important protein of …
Exploring The Relationship Between Art And Environmental Education, Mackenzie Haynes
Exploring The Relationship Between Art And Environmental Education, Mackenzie Haynes
Honors Projects
To explore the relationship between art and environmental education, I created a lesson plan and then put into practice at Crim Elementary School in a 4th grade art class. The art project had to do with the environment, endangered animals and recyclable materials. I titled the project "Habitat Heroes" and students had to imagine that they were the only people left on Earth along with a few animals and lots of trash. They were tasked with selecting an endangered animal in Ohio from one of five different groups (mammals, birds, reptiles/amphibians, birds and fish) to create a habitat for. The …
Assessing Environmental Factors That Influence Cyanobacterial Blooms In Skinn Lake, Kloe Atwood
Assessing Environmental Factors That Influence Cyanobacterial Blooms In Skinn Lake, Kloe Atwood
Honors Projects
Global lakes are experiencing an increase in toxic algal blooms that can be damaging to the environment. These blooms are caused by cyanobacteria, specifically a species called Planktothrix. Skinn Lake, in Ohio, is a location of a cyanobacterial bloom that is mainly populated by Planktothrix rubescens. This lake was further examined to identify the major toxin-producing bacteria and identify environmental microbes surrounding the bloom. When the data was examined it was found that the microbiomes of the lake greatly differed between the winter (bloom) months and the summer (non-bloom) months. This difference can be viewed within the nutrient analysis from …
How Corrective Lens Choices Are Associated With The Self-Esteem Of College Students, Margaret Neenan
How Corrective Lens Choices Are Associated With The Self-Esteem Of College Students, Margaret Neenan
Honors Projects
If you wear glasses or contacts, which one do you wear more often, and why? How Corrective Lens Choices are Associated with the Self-Esteem of College Students is an observational study on 1) how corrective lens choices are associated with the self-esteem of college students, and 2) how do factors such as gender, ethnicity, finances, insurance, recreational and occupational use, or lens options recommended to a patient impact an individual’s choice of corrective lenses. The observational study shows that there is no significant difference in the self-esteem of college students who wore a specific corrective lens more often. However, research …
Bci Validation: Yfiler Plus Kit Validation, Chloe Koon
Bci Validation: Yfiler Plus Kit Validation, Chloe Koon
Honors Projects
In order to have access and use the Combined DNA Index System (CODIS), it is required by the Federal Bureau of Investigation's Quality Assurance Standards (FBI-QAS) for Forensic DNA Units to complete comprehensive validation studies on all equipment, materials, and methods used in the process of DNA analysis. This study continues validation previous done within the Ohio Bureau of Criminal Investigation (BCI). YFiler Plus is a DNA amplification kit that is used in cases where it is most useful to examine only male DNA profile(s) within a sample by amplifying loci only on the Y-Chromosome. Components of this study include …
Plant Wise, Sophia Llamas
Plant Wise, Sophia Llamas
Honors Projects
Conceptually, Plant Wise is the key to bridging the gap between preconceived ideas about vegan and vegetarianism and successfully integrating plant-based foods into your everyday life. Physically, Plant Wise is a self-educational, interactive booklet chock-full of activities intended for users to complete at their own pace. Inside this 56-page booklet, there are recipes, doodling spaces, weekly check sheets, activities to do with friends and family, challenges, and so much more. Plant Wise utilizes these activities and journaling opportunities throughout as a self-reflective vehicle to give users an experience to reflect on, which aids in the retention of what’s been learned …
Isolating Bacteriophage For Potential Treatment Of Chronic Multi-Drug Resistant Escherichia Coli Infections, Leila Oswalt
Isolating Bacteriophage For Potential Treatment Of Chronic Multi-Drug Resistant Escherichia Coli Infections, Leila Oswalt
Honors Projects
The misuse and overuse of antibiotics has led to the intense rise in antibiotic resistance. As society transitions into the post antibiotic era, there will be a great need for new therapeutic strategies to address multiple drug resistant bacterial infections. One such method, called bacteriophage therapy, allows for specific targeting of certain pathogenic bacteria through the use of viruses that attack bacteria; termed “bacteriophage” or simply “phage”. Urinary tract infections are among the most common pathological human infections that rely heavily on the use of antibiotics, the major cause of which is the bacterium Escherichia coli. During the Spring 2021-Spring …