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Articles 1 - 12 of 12
Full-Text Articles in Life Sciences
Climate Warming’S Alteration Of Host-Parasite Dynamics, Ting-Hsuan Wu
Climate Warming’S Alteration Of Host-Parasite Dynamics, Ting-Hsuan Wu
Binghamton University Undergraduate Journal
Parasites and pathogens have significant roles in host population control, and thus host-parasite interactions affect biodiversity. The important question reviewed in this paper is how changes in temperature due to climate change affect host-parasite interactions. There is mounting evidence that elevated temperatures have both beneficial and detrimental effects on parasites and independently on hosts. These independent changes result in altered host-parasite dynamics through various mechanisms. If elevated temperatures enhance parasite survival, risk of disease transmission among hosts is enhanced as well. This enhancement is dependent on temperature-induced shifts in the host lifecycle, as asynchrony in host and parasite development can …
The Effect Of Intensified Illuminance And Artificial Light At Night On Fitness And Susceptibility To Abiotic And Biotic Stressors, Grascen Shidemantle
The Effect Of Intensified Illuminance And Artificial Light At Night On Fitness And Susceptibility To Abiotic And Biotic Stressors, Grascen Shidemantle
Biological Sciences Student Scholarship
Changing light conditions due to human activities represents an important emerging environmental concern. Although changes to natural light conditions can be independently detrimental, in nature, organisms commonly face multiple stressors. To understand the consequences of altered light conditions, we exposed a model amphibian (wood frog; Lithobates sylvaticus) to a control and two anthropogenic light conditions: intensified daytime illuminance and artificial light at night - ALAN (intensified daytime illuminance + extended photoperiod). We measured (1) metrics of fitness (hatching success as well as survival to, size at, and time to metamorphosis) (2) susceptibility (time to death) to a commonly cooccurring anthropogenic …
D-Glucose-6-Phosphate Stimulates Sags-Dependent Biofilm Formation In Pseudomonas Aeruginosa, Madison Gowett
D-Glucose-6-Phosphate Stimulates Sags-Dependent Biofilm Formation In Pseudomonas Aeruginosa, Madison Gowett
Undergraduate Honors Theses
The SagS protein is a two-component regulatory system in Pseudomonas aeruginosa that works to independently regulate biofilm formation and antibiotic tolerance. Previous work found that these two pathways are controlled by two distinct sets of amino acids within the sensory domain of SagS that are thought to be potential ligand binding sites. Despite the extensive research done on the structure and function of SagS, the signals that activate this protein have yet to be identified. In this study we aimed to identify ligands that stimulate SagS-dependent biofilm formation. To do this we utilized ΔsagS mutants, one harboring wild-type sagS under …
Parasite Susceptibility In An Amphibian Host Is Modified By Salinization And Predators, Nicholas Buss, Jessica Hua
Parasite Susceptibility In An Amphibian Host Is Modified By Salinization And Predators, Nicholas Buss, Jessica Hua
Biological Sciences Student Scholarship
Secondary salinization represents a global threat to freshwater ecosystems. Salts, such as NaCl, can be toxic to freshwater organisms and may also modify the outcome of species interactions (e.g. host-parasite interactions). In nature, hosts and their parasites are embedded in complex communities where they face anthropogenic and biotic (i.e. predators) stressors that influence host-parasite interactions. As human populations grow, considering how anthropogenic and natural stressors interact to shape host-parasite interactions will become increasingly important. We conducted two experiments investigating: (1) the effects of NaCl on tadpole susceptibility to trematodes and (2) whether density- and trait-mediated effects of a parasite-predator (i.e. …
Direct And Indirect Effects Of A Common Cyanobacterial Toxin On Amphibian-Echinostome Dynamics, Nicholas Buss, Matthew Wersebe, Jessica Hua
Direct And Indirect Effects Of A Common Cyanobacterial Toxin On Amphibian-Echinostome Dynamics, Nicholas Buss, Matthew Wersebe, Jessica Hua
Biological Sciences Student Scholarship
Wildlife diseases are emerging at unprecedented rates. While there are likely several factors at play, human-mediated environmental alterations may play a significant role. Of growing interest is the effect that microcystin-LR (MC-LR), a cyanotoxin, may have on disease outcomes. In this study, using an amphibian-trematode model we examined (1) the lethal effects of MC-LR on cercariae of trematodes; (2) the sublethal effects of MC-LR exposure on the ability for trematodes to infect green frog tadpoles; and (3) the sublethal effects of MC-LR on green frog tadpole susceptibility to trematodes. We found that environmentally-relevant concentrations of MC-LR at 50, 100, and …
Electrophysiological Characterization Of The Inhibitory Effects Of 2-Amino-4-Bis (Aryloxy Benzyl) Amino Butanoic Acids On Alanine Serine Cysteine Transporter 2 And Sodium Coupled Neutral Amino Acid Transporter 2, Paul Serguei Zakrepine
Electrophysiological Characterization Of The Inhibitory Effects Of 2-Amino-4-Bis (Aryloxy Benzyl) Amino Butanoic Acids On Alanine Serine Cysteine Transporter 2 And Sodium Coupled Neutral Amino Acid Transporter 2, Paul Serguei Zakrepine
Undergraduate Honors Theses
Alanine Serine Cysteine Transporter 2 (ASCT2) is a member of the solute carrier 1A (SLC1A) family of transport proteins. It is a Na+ dependent, obligatory neutral amino acid exchanger with the capability to transport glutamine and it is a primary glutamine transport protein in cancer cells. This glutamine transport capability confers an important physiological role for ASCT2 in the maintenance of intracellular amino acid pools for various metabolic and cell signaling pathways. Because of this, ASCT2 is found to be overexpressed in many cancers, which rely heavily on glutamine as an essential nutrient for cell survival and growth. A wealth …
Immune System Detection Of Pseudomonas Aeruginosa Persister Cells, Grace Elizabeth Himmler
Immune System Detection Of Pseudomonas Aeruginosa Persister Cells, Grace Elizabeth Himmler
Undergraduate Honors Theses
Persister cells are a subpopulation of bacterial cells known to be tolerant to antimicrobials. Their reduced susceptibility to antimicrobials allows them to be the source of recurrence of many chronic bacterial infections. As a result, it is vital to understand the mechanisms that allow these cells to be able to evade further treatment. Furthermore, it is currently unknown whether the persister cells are detected and killed by the host immune response. In this work I explored the host-pathogen interactions between Pseudomonas aeruginosa cells, both persister and regular, and human macrophages. I hypothesized that persister cells would be engulfed at a …
Optimization Of Adc Linkers: Design And Evaluation Of A Fret-Based Adc Linker-Library, Jared T. Miller
Optimization Of Adc Linkers: Design And Evaluation Of A Fret-Based Adc Linker-Library, Jared T. Miller
Undergraduate Honors Theses
Success of Antibody-drug conjugates (ADCs) relies on the maintained integrity of a chemical linker fusing a therapeutic payload to a monoclonal antibody. Recent reports have revealed the lead linker ValCitPABC has poor stability in rodent models compared to mammalian counterparts, resulting in many clinical investigations predicting poorer ADC efficacy due to premature payload release in these model systems. Optimization of this chemical linker to be resistant both in mouse and human models would streamline ADC progression into clinical trials. Herein we describe the synthesis and development of a FRET-based assay for evaluating linker stability in vitro. Evaluation of lysosomal release …
Analyses Of The 2019 Nobel Prize In Physiology Or Medicine: Molecular Machinery For Cellular Oxygen Level Response, Neyda V. Gilman
Analyses Of The 2019 Nobel Prize In Physiology Or Medicine: Molecular Machinery For Cellular Oxygen Level Response, Neyda V. Gilman
Library Scholarship
Gregg L. Semenza, William G Kaelin, Jr, and Sir Peter J. Ratcliffe were awarded the 2019 Nobel Prize for Physiology or Medicine on October 7, 2019. Their work led to the understanding of how cells recognize and adapt to varying oxygen levels. Hypoxia-inducible nuclear factors play an essential role in this mechanism by turning on other genes that work towards increasing oxygen levels in hypoxic environments. Other vital pieces of the machinery include von Hippel-Lindau proteins and prolyl hydroxylation. Due to the necessity of oxygen in numerous human physiological systems, this discovery will likely have nearly immeasurable impacts on human …
Impact Of Nacl Tolerance On The Stress Physiology And Fitness Of Larval Wood Frogs (Rana Sylvatica), Grascen Shidemantle, Nicholas Buss, Jessica Hua
Impact Of Nacl Tolerance On The Stress Physiology And Fitness Of Larval Wood Frogs (Rana Sylvatica), Grascen Shidemantle, Nicholas Buss, Jessica Hua
Biological Sciences Student Scholarship
No abstract provided.
Phenological Shifts In Amphibian Breeding Influences Offspring Size And Response To A Common Wetland Contaminant, Nicholas Buss, Lindsey Swierk, Jessica Hua
Phenological Shifts In Amphibian Breeding Influences Offspring Size And Response To A Common Wetland Contaminant, Nicholas Buss, Lindsey Swierk, Jessica Hua
Biological Sciences Student Scholarship
Increases in temperature variability associated with climate change has critical implications for the phenology of wildlife across the globe. Indeed, there have been many examples of warmer winter temperatures (i.e. “false springs”) inducing forward shifts in breeding phenology. Earlier breeding can put wildlife at risk of freeze events during reproduction or vulnerable early life stages. Furthermore, in addition to temperature shifts, wildlife populations commonly encounter a wide diversity of other stressors (e.g. pollutants). As global change is predicted to increase both temperature variability and instances of pollutant contamination, understanding interactions between these stressors will become increasingly important. Using 14 populations …
Size-Assortative Mating In Explosively Breeding Species: A Case Study Of Adaptive Male Mate Choice In An Anuran, Lindsey Swierk
Size-Assortative Mating In Explosively Breeding Species: A Case Study Of Adaptive Male Mate Choice In An Anuran, Lindsey Swierk
Biological Sciences Faculty Scholarship
No abstract provided.