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Full-Text Articles in Life Sciences

Regulation Of Satiety Quiescence: Cyclic Gmp, Tgf Beta, And The Asi Neuron, Thomas Gallagher Dec 2013

Regulation Of Satiety Quiescence: Cyclic Gmp, Tgf Beta, And The Asi Neuron, Thomas Gallagher

Theses and Dissertations

The worm Caenorhabditis elegans is a well-studied model organism in numerous aspects of its biology. This small free living nematode has less than 1,000 cells, but shows clear conservation in both signaling and behavior to mammals in aspects of appetite control. This is of importance to humans, where failure of appetite control is a major factor in the unprecedented obesity epidemic that we see today. In general, worm behavior reflects its internal nutritional state and the availability and quality of food. Specifically, worms show a behavioral state that mimics aspects of the mammalian behavioral satiety sequence, which has been termed …


The Thermoregulatory Theory Of Yawning: What We Know From Over Five Years Of Research, Andrew C. Gallup, Omar Tonsi Eldakar Jan 2013

The Thermoregulatory Theory Of Yawning: What We Know From Over Five Years Of Research, Andrew C. Gallup, Omar Tonsi Eldakar

Biology Faculty Articles

Over the past 5 years numerous reports have confirmed and replicated the specific brain cooling and thermal window predictions derived from the thermoregulatory theory of yawning, and no study has found evidence contrary to these findings. Here we review the comparative research supporting this model of yawning among homeotherms, while highlighting a recent report showing how the expression of contagious yawning in humans is altered by seasonal climate variation. The fact that yawning is constrained to a thermal window of ambient temperature provides unique and compelling support in favor of this theory. Heretofore, no existing alternative hypothesis of yawning can …


Guilty By Association: Time-Dependent Memory Consolidation And The Generalization Of Person-Specific Traits To Other Group Members, Luke R. Enge Jan 2013

Guilty By Association: Time-Dependent Memory Consolidation And The Generalization Of Person-Specific Traits To Other Group Members, Luke R. Enge

Open Access Theses & Dissertations

The following study investigated the extent to which time-dependent memory consolidation facilities the generalization of person-specific traits (individuated targets) to other, familiar social group members (familiar targets) Sixty-Nine (N = 69) participants learned to distinguish between two arbitrary groups, one positive and one negative. Participants learned the negative or positive information about a subset of the group members (individuated targets) and no individuating information about the familiar targets. Participants returned either without a time-delay containing sleep (2-6 hours after learning) or a time-delay with sleep (48 hours after learning). Results demonstrated that only after a time-delay containing sleep, negative information …


A One-Hour Sleep Restriction Impacts Brain Processing In Young Children Across Tasks: Evidence From Event-Related Potentials, Dennis Molfese, Anna Ivanenko, Alexandra P.F. Key, Adrienne Roman, Victoria J. Molfese, Louise M. O'Brien, David Gozal, Srinivas Kota, Caitlin M. Hudac Jan 2013

A One-Hour Sleep Restriction Impacts Brain Processing In Young Children Across Tasks: Evidence From Event-Related Potentials, Dennis Molfese, Anna Ivanenko, Alexandra P.F. Key, Adrienne Roman, Victoria J. Molfese, Louise M. O'Brien, David Gozal, Srinivas Kota, Caitlin M. Hudac

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

The effect of mild sleep restriction on cognitive functioning in young children is unclear, yet sleep loss may impact children's abilities to attend to tasks with high processing demands. In a preliminary investigation, six children (6.6 - 8.3 years of age) with normal sleep patterns performed three tasks: attention (“Oddball”), speech perception (conconant-vowel syllables) and executive function (Directional Stroop). Event-related potentials (ERP) responses were recorded before (Control) and following one-week of 1-hour per day of sleep restriction. Brain activity across all tasks following Sleep Restriction differed from activity during Control Sleep, indicating that minor sleep restriction impacts children's neurocognitive functioning.


Post-Traumatic Sleep Following Diffuse Traumatic Brain Injury, Rachel K. Rowe Jan 2013

Post-Traumatic Sleep Following Diffuse Traumatic Brain Injury, Rachel K. Rowe

Theses and Dissertations--Neuroscience

Traumatic brain injury (TBI) is a major cause of death and disability throughout the world with few pharmacological treatments available for individuals who suffer from neurological morbidities associated with TBI. Cellular and molecular pathological processes initiated at the time of injury develop into neurological impairments, with chronic sleep disorders (insomnia, hypersomnolence) being among the somatic, cognitive and emotional neurological impairments. Immediately post-injury, TBI patients report excessive daytime sleepiness, however, discordant opinions suggest that individuals should not be allowed to sleep or should be frequently awoken following brain injury. To provide adequate medical care, it is imperative to understand the role …