Life Sciences Commons^™

Comparative Metabolism Of Benzo(A)Pyrene By Ovarian Microsomes Of Various Species, Deacqunita L. Harris, Ashley C. Huderson, Mohammad S. Niaz, J. Joe Ford, Anthony E. Archibong, Aramandla Ramesh

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Knowledge of the ability of the female reproductive system to metabolize polycyclic aromatic hydrocarbons (PAHs) is critical to the diagnosis and management of female infertility and for risk assessment purposes. The PAHs are a family of widespread pollutants that are released into the environment from automobile exhausts, cigarette smoke, burning of refuse, industrial emissions, and hazardous waste sites. In exposed animals, PAHs become activated to reactive metabolites that interfere with target organ function and as a consequence cause toxicity. The extent of susceptibility to PAH exposure may depend on the ability of animals to metabolize these chemicals. The present study …