Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement, E. Diamanti-Kandarakis, J. P. Bourguignon, L. C. Giudice, R. Hauser, G. S. Prins, A. M. Soto, R. Thomas Zoeller, A. C. Gore
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement, E. Diamanti-Kandarakis, J. P. Bourguignon, L. C. Giudice, R. Hauser, G. S. Prins, A. M. Soto, R. Thomas Zoeller, A. C. Gore
R. Thomas Zoeller
There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction. In this first Scientific Statement of The Endocrine Society, we present the evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology. Results from animal models, human clinical observations, and epidemiological studies converge to implicate EDCs as a significant concern to public health. …
Identification Of Thyroid Hormone Receptor Binding Sites And Target Genes Using Chip-On-Chip In Developing Mouse Cerebellum, H. Dong, C. L. Yauk, A. Rowan-Carroll, S. H. You, R. Thomas Zoeller, I Lambert, M. G. Wade
Identification Of Thyroid Hormone Receptor Binding Sites And Target Genes Using Chip-On-Chip In Developing Mouse Cerebellum, H. Dong, C. L. Yauk, A. Rowan-Carroll, S. H. You, R. Thomas Zoeller, I Lambert, M. G. Wade
R. Thomas Zoeller
Thyroid hormone (TH) is critical to normal brain development, but the mechanisms operating in this process are poorly understood. We used chromatin immunoprecipitation to enrich regions of DNA bound to thyroid receptor beta (TRβ) of mouse cerebellum sampled on post natal day 15. Enriched target was hybridized to promoter microarrays (ChIP-on-chip) spanning −8 kb to +2 kb of the transcription start site (TSS) of 5000 genes. We identified 91 genes with TR binding sites. Roughly half of the sites were located in introns, while 30% were located within 1 kb upstream (5′) of the TSS. Of these genes, 83 with …
Why Public Health Agencies Cannot Depend On Good Laboratory Practices As A Criterion For Selecting Data: The Case Of Bisphenol A, I Chahoud, F. S. Vom Saal, B. T. Akingbemi, S. M. Belcher, D. A. Crain, D. Crews, L. C. Guidice, P. A. Hunt, F. Farabollini, L. J. Guillette Jr., T. Hassold, S. M. Ho, K. Arizono, T. Colborn, T. Iguchi, S. Jobling, J. Kanno, H. Laufer, M. Marcus, A. Nadal, J. A. Mclachlan, J Oehlmann, N. Olea, P. Palanza, S. Parmigiani, B. S. Rubin, G. Schoenfelder, C. Sonnenschein, A. M. Soto, C. E. Talsness, J. A. Taylor, L. N. Vandenberg, J. G. Vandenbergh, S. Vogel, C. S. Watson, W. V. Welshons, R. Thomas Zoeller
Why Public Health Agencies Cannot Depend On Good Laboratory Practices As A Criterion For Selecting Data: The Case Of Bisphenol A, I Chahoud, F. S. Vom Saal, B. T. Akingbemi, S. M. Belcher, D. A. Crain, D. Crews, L. C. Guidice, P. A. Hunt, F. Farabollini, L. J. Guillette Jr., T. Hassold, S. M. Ho, K. Arizono, T. Colborn, T. Iguchi, S. Jobling, J. Kanno, H. Laufer, M. Marcus, A. Nadal, J. A. Mclachlan, J Oehlmann, N. Olea, P. Palanza, S. Parmigiani, B. S. Rubin, G. Schoenfelder, C. Sonnenschein, A. M. Soto, C. E. Talsness, J. A. Taylor, L. N. Vandenberg, J. G. Vandenbergh, S. Vogel, C. S. Watson, W. V. Welshons, R. Thomas Zoeller
R. Thomas Zoeller
Background In their safety evaluations of bisphenol A (BPA), the U.S. Food and Drug Administration (FDA) and a counterpart in Europe, the European Food Safety Authority (EFSA), have given special prominence to two industry-funded studies that adhered to standards defined by Good Laboratory Practices (GLP). These same agencies have given much less weight in risk assessments to a large number of independently replicated non-GLP studies conducted with government funding by the leading experts in various fields of science from around the world. Objectives We reviewed differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and …
Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers Of Adverse Outcomes, M. D. Miller, K. M. Crofton, D. C. Rice, R. Thomas Zoeller
Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers Of Adverse Outcomes, M. D. Miller, K. M. Crofton, D. C. Rice, R. Thomas Zoeller
R. Thomas Zoeller
Background There is increasing evidence in humans and in experimental animals for a relationship between exposure to specific environmental chemicals and perturbations in levels of critically important thyroid hormones (THs). Identification and proper interpretation of these relationships are required for accurate assessment of risk to public health. Objectives We review the role of TH in nervous system development and specific outcomes in adults, the impact of xenobiotics on thyroid signaling, the relationship between adverse outcomes of thyroid disruption and upstream causal biomarkers, and the societal implications of perturbations in thyroid signaling by xenobiotic chemicals. Data sources We drew on an …
A Clash Of Old And New Scientific Concepts In Toxicity, With Important Implications For Public Health, J. P. Myers, R. Thomas Zoeller, F. S. Vom Saal
A Clash Of Old And New Scientific Concepts In Toxicity, With Important Implications For Public Health, J. P. Myers, R. Thomas Zoeller, F. S. Vom Saal
R. Thomas Zoeller
Background A core assumption of current toxicologic procedures used to establish health standards for chemical exposures is that testing the safety of chemicals at high doses can be used to predict the effects of low-dose exposures, such as those common in the general population. This assumption is based on the precept that “the dose makes the poison”: higher doses will cause greater effects. Objectives We challenge the validity of assuming that high-dose testing can be used to predict low-dose effects for contaminants that behave like hormones. We review data from endocrinology and toxicology that falsify this assumption and summarize current …