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Synthesis Of Some Novel Thiazole, Thiophene, Thienopyridine And Thienopyrimidine Derivatives Containing Tosyl Moiety, S. Hessien, Mona Kadah, N. Marzouk
Synthesis Of Some Novel Thiazole, Thiophene, Thienopyridine And Thienopyrimidine Derivatives Containing Tosyl Moiety, S. Hessien, Mona Kadah, N. Marzouk
Al-Azhar Bulletin of Science
Interaction of 4-aminoacetophenone (1) with p-tolyl sulphonamide afforded 1-[4-tosyl amino) phenyl]ethanone (2). Treatment of 2 with bromine water yielded 2-bromo-1-[4-tosyl amino) phenyl]ethanone (3), which reacted with thiourea to give 2-amino thiazole derivative (4). Compound 2 was condensed with phenyl acetaldehyde and malononitrile to give derivatives (5) and (7), which were respectively reacted with o-aminothiophenol and carbon disulfide to give derivatives (6) and (9). Reaction of 7 under Gewald reaction condition afforded the thiophen-3-carbonitrile derivative (11) which consequently reacted with 4-fluorobenzylidinemalononitrile, phenyl isothiocyanate to give compounds 12 and 15, respectively. The structures of these compounds were confirmed by infrared, mass and …