Life Sciences Commons^™

Part 1: Synthesis And Reactions Of Some New Pyrazolo[4,5-D]Imidazole Derivatives And Screening Their Antibacterial And Antitumor Activities, Nahed Abd El-Ghaffar, Mona Kadah, Azza Radwan, Sara Abd El-Al, Asmaa Salman

Al-Azhar Bulletin of Science

Reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with diazotized aromatic amines gave the corresponding diazenyl derivatives 1, which were condensed with carbonyl compounds to give the arylidene derivatives 2. Reaction of the parent pyrazolone with urea, thiourea and guanidine gave the pyrazoloimidazole derivatives 3. compound 3a reacted with thiourea in DMF to give the thiourea derivative 4. The reaction of 4 with malonic acid and acetyl chloride gave the pyrimidinedione derivative 5, which on reaction with thiourea in presence of sodium ethoxide gave the triazine derivative 6. S-alkylation of 6 with ethyl chloroacetate gave the ethyl acetate derivative 7, which on hydrolysis gave the …