Life Sciences Commons^™

The Genome Scale Metabolic Model Of Cryptosporidium Hominis: Inv209, Niti Vanee

Theses and Dissertations

The apicomplexan Cryptosporidium is a protozoan parasite of humans and other mammals. Cryptosporidium species cause acute gastro-enteritis and diarrheal disease in healthy humans and animals, and cause life-threatening infection in immuno-compromised individuals such as people with AIDS. It has a one-host life cycle and invades intestinal epithelial cells causing diarrhea, or more rarely the pulmonary epithelium. Cryptosporidium carries out all the asexual reproductive stages like several other apicomplexans. Current annotation of this organism predicts it to contain 3884 genes of which only 1581 genes have predicted functions. By using a combination of bioinformatics analysis, biochemical evidence, and high-throughput data, a …