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Novel Neuroprotectants For Sarin Plus Cbdp Induced Convulsions, Kaushal V. Joshi
Novel Neuroprotectants For Sarin Plus Cbdp Induced Convulsions, Kaushal V. Joshi
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Sarin, also known as Sarin (German agent B) is classified as a weapon of mass destruction. Sarin (O-isopropyl methyl phosphonofluoridate) is a highly toxic nerve agent originally produced for chemical warfare and has been used in terrorist activities. Sarin is an extremely potent acetylcholinesterase inhibitor with high specificity and affinity for the enzyme. High sarin doses causes death due to anoxia resulting from airway obstruction, weakness of the muscles of respiration, respiratory failure and convulsions. Current treatments are still not effective at protecting against long term effects following exposure. A current approach aims to counteract the increased glutamatergic and cholinergic …
Effect Of Low-Dose Sarin Exposure On The Neurochemistry Of Different Brain Structures In Mice, Dhawal Pravin Oswal
Effect Of Low-Dose Sarin Exposure On The Neurochemistry Of Different Brain Structures In Mice, Dhawal Pravin Oswal
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Sarin (GB) is a toxic organophosphate (OP) nerve agent that was released in the Gulf War and was used in terrorist attacks in Japan. People who survive such attacks exhibit various long-term effects including alterations in neuropsychological performances. It has also been hypothesized that the Gulf War Illness could be a result of low level exposure to OP's. In order to understand the effect of low dose exposure to GB on physiological and behavioral functions, we analyzed the levels of monoamines and their metabolites in different brain areas after exposure of mice to a sublethal dose of GB. Mice (male …