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Co-Regulation Of A Large And Rapidly Evolving Repertoire Of Odorant Receptor Genes, Robert P. Lane
Co-Regulation Of A Large And Rapidly Evolving Repertoire Of Odorant Receptor Genes, Robert P. Lane
Robert P. Lane
The olfactory system meets niche- and species-specific demands by an accelerated evolution of its odorant receptor repertoires. In this review, we describe evolutionary processes that have shaped olfactory and vomeronasal receptor gene families in vertebrate genomes. We emphasize three important periods in the evolution of the olfactory system evident by comparative genomics: the adaptation to land in amphibian ancestors, the decline of olfaction in primates, and the delineation of putative pheromone receptors concurrent with rodent speciation. The rapid evolution of odorant receptor genes, the sheer size of the repertoire, as well as their wide distribution in the genome, presents a …
Species Specificity In Rodent Pheromone Receptor Repertoires, Robert P. Lane
Species Specificity In Rodent Pheromone Receptor Repertoires, Robert P. Lane
Robert P. Lane
No abstract provided.
V1r Promoters Are Well Conserved And Exhibit Common Putative Regulatory Motifs, Robert P. Lane
V1r Promoters Are Well Conserved And Exhibit Common Putative Regulatory Motifs, Robert P. Lane
Robert P. Lane
BACKGROUND: The mouse vomeronasal organ (VNO) processes chemosensory information, including pheromone signals that influence reproductive behaviors. The sensory neurons of the VNO express two types of chemosensory receptors, V1R and V2R. There are ~165 V1R genes in the mouse genome that have been classified into ~12 divergent subfamilies. Each sensory neuron of the apical compartment of the VNO transcribes only one of the repertoire of V1R genes. A model for mutually exclusive V1R transcription in these cells has been proposed in which each V1R gene might compete stochastically for a single transcriptional complex. This model predicts that the large repertoire …
Divergent V1r Repertoires In Five Species: Amplification In Rodents, Decimation In Primates, And A Surprisingly Small Repertoire In Dogs, Robert P. Lane
Divergent V1r Repertoires In Five Species: Amplification In Rodents, Decimation In Primates, And A Surprisingly Small Repertoire In Dogs, Robert P. Lane
Robert P. Lane
The V1R gene family comprises one of two types of putative pheromone receptors expressed in the mammalian vomeronasal organ (VNO). We searched the most recent mouse, rat, dog, chimpanzee, and human genome sequence assemblies to compile a near-complete repertoire of V1R genes for each species. Dog, human, and chimpanzee have very few intact V1Rs (8, 2, and 0, respectively) compared to more than a hundred intact V1Rs in each of the rat (106) and mouse (165) genomes. We also provide the first description of the diversity of V1R pseudogenes in these species. We identify at least 165 pseudogenes in mouse, …