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Molecular Dynamics Study Of Single Stranded Peptide Nucleic Acids, Anna K. Manukyan
Molecular Dynamics Study Of Single Stranded Peptide Nucleic Acids, Anna K. Manukyan
Theses and Dissertations in Biomedical Sciences
A PNA molecule is a DNA strand where the sugar-phosphate backbone has been replaced by a structurally homomorphous pseudopeptide chain consisting of N(2-aminoethyl)-glycine units. PNA binds strongly to both DNA and RNA. However, an analysis of the X-ray and NMR data show that the dihedral angles of PNA/DNA or PNA/DNA complexes are very different from those of DNA:DNA or RNA:RNA complexes. In addition, the PNA strand is very flexible. One way to improve the binding affinity of PNA for DNA/RNA is to design a more pre-organized PNA structure. An effective way to rigidify the PNA strand is to introduce …