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Cocaine And Mefloquine-Induced Acute Effects In Ventral Tegmental Area Dopamine And Gaba Neurons, David Wilbanks Allison
Cocaine And Mefloquine-Induced Acute Effects In Ventral Tegmental Area Dopamine And Gaba Neurons, David Wilbanks Allison
Theses and Dissertations
The aim of the two studies presented here was to evaluate the effects of cocaine and mefloquine (MFQ) on γ-aminobutyric acid (GABA) and dopamine (DA) neurons in the ventral tegmental area (VTA). Cocaine: In vivo, lower doses of intravenous cocaine (0.25-0.5 mg/kg), or methamphetamine (METH), enhanced VTA GABA neuron firing rate via D2/D5 receptor activation. Higher cocaine doses (1.0-2.0 mg/kg) inhibited their firing rate. Cocaine and lidocaine inhibited the firing rate and spike discharges induced by stimulation of the internal capsule (ICPSDs) at dose levels 0.25-2 mg/kg (IC50 1.2 mg/kg), but neither DA nor METH reduced ICPSDs. In VTA …