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Full-Text Articles in Life Sciences
Evolutionary And Functional Insights Into The Mechanism Underlying High-Altitude Adaptation Of Deer Mouse Hemoglobin, Jay F. Storz, Amy M. Runck, Stephen J. Sabatino, John K. Kelly, Nuno Ferrand, Hideaki Moriyama, Roy E. Weber, Angela Fago
Evolutionary And Functional Insights Into The Mechanism Underlying High-Altitude Adaptation Of Deer Mouse Hemoglobin, Jay F. Storz, Amy M. Runck, Stephen J. Sabatino, John K. Kelly, Nuno Ferrand, Hideaki Moriyama, Roy E. Weber, Angela Fago
Jay F. Storz Publications
Adaptive modifications of heteromeric proteins may involve genetically based changes in single subunit polypeptides or parallel changes in multiple genes that encode distinct, interacting subunits. Here we investigate these possibilities by conducting a combined evolutionary and functional analysis of duplicated globin genes in natural populations of deer mice (Peromyscus maniculatus) that are adapted to different elevational zones. A multilocus analysis of nucleotide polymorphism and linkage disequilibrium revealed that high-altitude adaptation of deer mouse hemoglobin involves parallel functional differentiation at multiple unlinked gene duplicates: two α-globin paralogs on chromosome 8 and two β-globin paralogs on chromosome 1. Differences in …
Molecular Evolution Of Cytochrome B In High- And Low-Altitude Deer Mice (Genus Peromyscus), E. J. Gering, J. C. Opazo, Jay F. Storz
Molecular Evolution Of Cytochrome B In High- And Low-Altitude Deer Mice (Genus Peromyscus), E. J. Gering, J. C. Opazo, Jay F. Storz
Jay F. Storz Publications
Patterns of amino-acid polymorphism in human mitochondrial genes have been interpreted as evidence for divergent selection among populations that inhabit climatically distinct environments. If similar patterns are mirrored in other broadly distributed mammalian species, then adaptive modifications of mitochondrial protein function may be detected in comparisons among locally adapted populations of a single wide-ranging species, or among closely related species that have adapted to different environments. Here, we test for evidence of positive selection on cytochrome b variation within and among species of the ecologically diverse rodent genus Peromyscus. We used likelihood-based comparisons of synonymous and nonsynonymous substitution rates to …
Evolution Of Duplicated Β-Globin Genes And The Structural Basis Of Hemoglobin Isoform Differentiation In Mus, Amy M. Runck, Hideaki Moriyama, Jay F. Storz
Evolution Of Duplicated Β-Globin Genes And The Structural Basis Of Hemoglobin Isoform Differentiation In Mus, Amy M. Runck, Hideaki Moriyama, Jay F. Storz
Jay F. Storz Publications
The functional diversification of multigene families may be strongly influenced by mechanisms of concerted evolution such as interparalog gene conversion. The β-globin gene family of house mice (genus Mus) represents an especially promising system for evaluating the effects of gene conversion on the functional divergence of duplicated genes. Whereas the majority of mammalian species possess tandemly duplicated copies of the adult β-globin gene that are identical in sequence, natural populations of house mice are often polymorphic for distinct two-locus haplotypes that differ in levels of functional divergence between duplicated β-globin genes, HBB-T1 and HBB-T2. Here, we use a phylogenetic …
Gene Duplication And The Resolution Of Adaptive Conflict, Jay F. Storz
Gene Duplication And The Resolution Of Adaptive Conflict, Jay F. Storz
Jay F. Storz Publications
Gene duplication is known to play an important role in the evolution of novel protein functions. However, there is still much debate about the evolutionary mechanisms that are responsible for the initial retention and subsequent divergence of newly created gene duplicates (Lynch et al., 2001; Zhang, 2003; Lynch and Katju, 2004; Taylor and Raes, 2004). According to the neofunctionalization (NEOF) model of Ohno (1970), the functional redundancy of duplicated genes entails a relaxation of purifying selection that results in the accumulation of degenerative mutations in one gene copy, while the other duplicate copy continues to perform the essential tasks of …
Origin And Ascendancy Of A Chimeric Fusion Gene: The Β/Δ-Globin Gene Of Paenungulate Mammals, Juan C. Opazo, Angela M. Sloan, Kevin L. Campbell, Jay F. Storz
Origin And Ascendancy Of A Chimeric Fusion Gene: The Β/Δ-Globin Gene Of Paenungulate Mammals, Juan C. Opazo, Angela M. Sloan, Kevin L. Campbell, Jay F. Storz
Jay F. Storz Publications
The δ-globin gene (HBD) of eutherian mammals exhibits a propensity for recombinational exchange with the closely linked β-globin gene (HBB) and has been independently converted by the HBB gene in multiple lineages. Here we report the presence of a chimeric β/δ fusion gene in the African elephant (Loxodonta africana) that was created by unequal crossing-over between misaligned HBD and HBB paralogs. The recombinant chromosome that harbors the β/δ fusion gene in elephants is structurally similar to the ‘‘anti-Lepore’’ duplication mutant of humans (the reciprocal exchange product of the hemoglobin Lepore deletion mutant). However, the situation in …