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Pdi, Reactive Oxygen Species Stress And Polyphenolic Phytochemicals: Implications For Neurodegenerative Diseases, Rituraj Pal
Pdi, Reactive Oxygen Species Stress And Polyphenolic Phytochemicals: Implications For Neurodegenerative Diseases, Rituraj Pal
Open Access Theses & Dissertations
PDI, protein disulfide isomerase, is one of the most versatile proteins and highly expressed in mammalian cells because there is a vast number of proteins that must undergo processing before secretion to their final destinations. PDI has several functions: oxidation of nascent proteins and isomerization of existing disulfide bonds. It also possesses chaperone activity and participates in protein degradation. Because of its structure, PDI can exist in a reduced or oxidized form. In mammalian cells it is mostly reduced due to the high demand of disulfide bond shuffling of secreted proteins within the ER, PDI a, a', and b' posses …