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Differential Expression Of Collagen Type V And Xi Α-1 In Human Ascending Thoracic Aortic Aneurysms, Julia Thom Oxford
Differential Expression Of Collagen Type V And Xi Α-1 In Human Ascending Thoracic Aortic Aneurysms, Julia Thom Oxford
Biomolecular Research Center Publications and Presentations
Background—The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal process.
Methods—Surgical samples from ascending aortas from patients with degenerative ATAAs were subdivided by aneurysm diameter: small, 5 to 6 cm; medium, 6 to 7 cm; and large, greater than 7 cm; and compared with nonaneurysmal aortas (mean diameter, 2.3 cm).
Results—Histology, immunofluorescence, and electron microscopy demonstrated greater disorganization of extracellular matrix constituents in ATAAs as compared with control with an increase in collagen α1(XI) within regions of cystic medial …