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Fractional Factorial Design Approach For Studying In Vitro Transdermal Delivery Of Granisetron Using Electroporation, Samia Nour, Mohamed Elewa, Randa Abd El-Rehim
Fractional Factorial Design Approach For Studying In Vitro Transdermal Delivery Of Granisetron Using Electroporation, Samia Nour, Mohamed Elewa, Randa Abd El-Rehim
Al-Azhar Bulletin of Science
Granisetron Hydrochloride is a 5-hydroxytryptamine 3 (5-HT3) receptor antagonist used for the prevention and treatment of nausea and vomiting associated with cancer chemotherapy. Based on the hydrophilicity of this drug (pka=9.4) it is unlikely that passive diffusion across the skin could deliver therapeutic amounts from a large sized patch. This study was conducted to evaluate the feasibility of in vitro transdermal delivery of granisetron using electroporation across full thickness hairless rat skin. A 24-1fractional factorial design was used to determine the most important variables affecting the transdermal delivery of granisetron using electroporation. The variables studied and respective levels investigated were …