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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Capsaicin Is A Negative Allosteric Modulator Of The 5-Ht3 Receptor, Eslam El Nebrisi, Tatiana Prytkova, Dietrich Ernst Lorke, Luke Howarth, Asma Hassan Alzaabi, Keun-Hang Susan Yang, Frank Christopher Howarth, Murat Oz
Capsaicin Is A Negative Allosteric Modulator Of The 5-Ht3 Receptor, Eslam El Nebrisi, Tatiana Prytkova, Dietrich Ernst Lorke, Luke Howarth, Asma Hassan Alzaabi, Keun-Hang Susan Yang, Frank Christopher Howarth, Murat Oz
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
In this study, effects of capsaicin, an active ingredient of the capsicum plant, were investigated on human 5-hydroxytryptamine type 3 (5-HT3) receptors. Capsaicin reversibly inhibited serotonin (5-HT)-induced currents recorded by two-electrode voltage clamp method in Xenopus oocytes. The inhibition was time- and concentration-dependent with an IC50 = 62 μM. The effect of capsaicin was not altered in the presence of capsazepine, and by intracellular BAPTA injections or trans-membrane potential changes. In radio-ligand binding studies, capsaicin did not change the specific binding of the 5-HT3 antagonist [3H]GR65630, indicating that it is a noncompetitive inhibitor of …
Dietary Antioxidants Impact Ddt Resistance In Drosophila Melanogaster, Gamal A. M. Abdu-Allah, Keon-Mook Seong, Omprakash Mittapalli, James Adebayo Ojo, Weilin Sun, Omar Posos-Parra, David Mota-Sanchez, John M. Clark, Barry R. Pittendrigh
Dietary Antioxidants Impact Ddt Resistance In Drosophila Melanogaster, Gamal A. M. Abdu-Allah, Keon-Mook Seong, Omprakash Mittapalli, James Adebayo Ojo, Weilin Sun, Omar Posos-Parra, David Mota-Sanchez, John M. Clark, Barry R. Pittendrigh
Entomology Faculty Publications
Insects experience a diversity of subtoxic and/or toxic xenobiotics through exposure to pesticides and, in the case of herbivorous insects, through plant defensive compounds in their diets. Many insects are also concurrently exposed to antioxidants in their diets. The impact of dietary antioxidants on the toxicity of xenobiotics in insects is not well understood, in part due to the challenge of developing appropriate systems in which doses and exposure times (of both the antioxidants and the xenobiotics) can be controlled and outcomes can be easily measured. However, in Drosophila melanogaster, a well-established insect model system, both dietary factors and …
The Effect Of Bacterial Endotoxin Lps On Serotonergic Modulation Of Glutamatergic Synaptic Transmission, Jate Bernard, Abigail Greenhalgh, Oscar Istas, Nicole T. Marguerite, Robin L. Cooper
The Effect Of Bacterial Endotoxin Lps On Serotonergic Modulation Of Glutamatergic Synaptic Transmission, Jate Bernard, Abigail Greenhalgh, Oscar Istas, Nicole T. Marguerite, Robin L. Cooper
Biology Faculty Publications
The release of the endotoxin lipopolysaccharides (LPS) from gram-negative bacteria is key in the induction of the downstream cytokine release from cells targeting cells throughout the body. However, LPS itself has direct effects on cellular activity and can alter synaptic transmission. Animals experiencing septicemia are generally in a critical state and are often treated with various pharmacological agents. Since antidepressants related to the serotonergic system have been shown to have a positive outcome for septicemic conditions impacting the central nervous system, the actions of serotonin (5-HT) on neurons also exposed to LPS were investigated. At the model glutamatergic synapse of …
Brain-Encysting Trematodes (Euhaplorchis Californiensis) Decrease Raphe Serotonergic Activity In California Killifish (Fundulus Parvipinnis), Siri H. Helland-Riise, Marco A. Vindas, Ida B. Johansen, Lauren E. Nadler, Kelly L. Weinersmith, Ryan F. Hechinger, Øyvind Øverli
Brain-Encysting Trematodes (Euhaplorchis Californiensis) Decrease Raphe Serotonergic Activity In California Killifish (Fundulus Parvipinnis), Siri H. Helland-Riise, Marco A. Vindas, Ida B. Johansen, Lauren E. Nadler, Kelly L. Weinersmith, Ryan F. Hechinger, Øyvind Øverli
Marine & Environmental Sciences Faculty Articles
Modulation of brain serotonin (5-HT) signalling is associated with parasite-induced changes in host behaviour, potentially increasing parasite transmission to predatory final hosts. Such alterations could have substantial impact on host physiology and behaviour, as 5-HT serves multiple roles in neuroendocrine regulation. These effects, however, remain insufficiently understood, as parasites have been associated with both increased and decreased serotonergic activity. Here, we investigated effects of trematode Euhaplorchis californiensis metacercariae on post-stress serotonergic activity in the intermediate host California killifish (Fundulus parvipinnis). This parasite is associated with conspicuous behaviour and increased predation of killifish by avian end-hosts, as well as …
Serotonin 5-Ht2a And 5-Ht2c Receptors Regulate Rat Maternal Behavior Through Distinct Behavioral And Neural Mechanisms, Jun Gao, Lina Nie, Yu Li, Ming Li
Serotonin 5-Ht2a And 5-Ht2c Receptors Regulate Rat Maternal Behavior Through Distinct Behavioral And Neural Mechanisms, Jun Gao, Lina Nie, Yu Li, Ming Li
Department of Psychology: Faculty Publications
Serotonin 5-HT2A and 5-HT2C receptors play important yet distinctive roles in the regulation of rat maternal behavior. The present study investigated their neural substrates and explored the possible behavioral mechanisms (i.e., behavioral organization or maternal motivation). Sprague-Dawley postpartum females were microinjected with either a selective 5-HT2A agonist (TCB-2, 0.4 or 4.0 μg/side) or a 5-HT2C agonist (MK212, 2.5 or 5.0 μg/side) into the medial prefrontal cortex (mPFC) or ventral tegmental area (VTA). Ten and 60 min later, their maternal activities were observed in the home cage; and their motivational responses towards pups were examined in a …