Life Sciences Commons^™

Apoe Stabilization By Exercise Prevents Aging Neurovascular Dysfunction And Complement Induction, Ileana Soto Reyes, Leah C. Graham, Hannah J. Richter, Stephen N. Simeone, Jake E. Radell, Weronika Grabowska, W. Keith Funkhouser, Megan C. Howell, Gareth R. Howell

Ileana Soto Reyes

Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related decline of brain structures and function. Here we use RNA-seq in combination with high resolution histological analyses to show that aging leads to a significant deterioration of neurovascular structures including basement membrane reduction, pericyte loss, and astrocyte dysfunction. Neurovascular decline was sufficient to cause vascular leakage and correlated strongly with an increase in neuroinflammation including up-regulation of complement component C1QA in microglia/monocytes. Importantly, long-term aerobic exercise from midlife to old age prevented this age-related neurovascular decline, …

The Impact Of Power Training On Balance And Visual Feedback Removal, Juliana Bouton

Juliana Bouton

Metastable Pain-Attention Dynamics During Incremental Exhaustive Exercise, Agnė Slapšinskaitė, Robert Hristovski, Selen Razon, Natàlia Balagué, Gershon Tenenbaum

Selen Razon

No abstract provided.

Towards A Home-Based Virtual Reality Game System To Promote Exercise, Ashish Amresh, Rahul Salla

Ashish Amresh

Spirometry Measurements During An Episode Of Exercise-Related Transient Abdominal Pain, Darren Morton

Darren Morton

Purpose: To determine whether changes in lung function are associated with exercise-related transient abdominal pain (ETAP). Methods: Twenty-eight subjects susceptible to ETAP performed a flow-volume loop before (pre) and after (post) treadmill exercise. Fourteen of the subjects developed symptoms of ETAP during the exercise and completed the flow-volume loop while the pain was present. The remaining 14 subjects reported no symptoms of ETAP. Results: Forced inspiratory vital capacity was essentially unchanged from pre to post in both groups (ETAP group –0.8% ± 5.1%, comparison group –0.9% ± 6.5%). Peak inspiratory-flow rate increased in both the ETAP group (12.4% ± 16.2%) …

The Role Of Equipment, The Physical Environment And Training Practices In Customer Safety Within Fitness Facilities: The Perspectives Of Fitness Industry Employees, Shannon E. Gray, Patrick Keyzer, Kevin Norton, Joachim Dietrich, Betul Sekendiz, Ian Coyle, Caroline F. Finch

Joachim Dietrich

Introduction: Fitness facilities provide an avenue for people to engage in physical activity; however, it is important that these facilities have effective strategies to reduce the risk of injuries to their customers. The attitudes of fitness industry employees with respect to safety can influence the implementation of risk management practices that can then impact on the success of such strategies. The aim of this study was to identify views of nationwide fitness industry employees about safety hazards associated with equipment, training practices and the physical environments within fitness facilities. Methods: A 6-week nationwide online cross-sectional self-report survey consisting of 13 …

The Effects Of Home-Based Pilates In Healthy College-Age Females, Betsy Donahoe-Fillmore, Mary Insana Fisher, C. Jayne Brahler

Betsy Donahoe-Fillmore

Objectives: To quantify and determine the effects of Pilates on core endurance, hamstring flexibility, balance, body composition/mass and perceived stress level in healthy college age females. Study Design: Randomized controlled trial design. Background: Emerging research on the Pilates technique is inconclusive regarding benefits to core endurance, flexibility, balance, body mass, and perceived stress. Methods and Measures: Female college students (n=57; 18-35 years old) were randomly assigned to a Pilates group, who exercised at home with a DVD, or a control group who did not engage in Pilates practice. Core endurance, hamstring flexibility, balance, body composition and stress measurements were taken …

Exhaustive Exercise Training Enhances Aerobic Capacity In American Alligator (Alligator Mississippiensis), John Eme, Tomasz Owerkowicz, June Gwalthney, Jason M. Blank, Bryan C. Rourke, James W. Hicks

James Hicks

The oxygen transport system in mammals is extensively remodelled in response to repeated bouts of activity, but many reptiles appear to be ‘metabolically inflexible’ in response to exercise training. A recent report showed that estuarine crocodiles (Crocodylus porosus) increase their maximum metabolic rate in response to exhaustive treadmill training, and in the present study, we confirm this response in another crocodilian, American alligator (Alligator mississippiensis). We further specify the nature of the crocodilian training response by analysing effects of training on aerobic [citrate synthase (CS)] and anaerobic [lactate dehydrogenase (LDH)] enzyme activities in selected skeletal muscles, ventricular and skeletal muscle …

Physically Interactive Games Increase Vo2 Above Resting Metabolic Rate, Shaelee Allen, Jacob E. Barkley, Janet Dufek, Paul Hafen, Michael Jarrett, Krystina Moschella, James Navalta, Robert Rietjens, Richard Tandy, Antonio Santo

Jacob E Barkley

The purpose of this study was to determine the energy cost, beyond resting metabolic rate (RMR), of playing select games on the Nintendo Wii for 30 contiguous minutes. Physically interactive games (i.e. Basic Run and Basic Step) increase energy expenditure above resting values compared to a sedentary game (Tanks!) and therefore may help individual’s become more active. Furthermore, Basic Run and Basic Step elicited MET values of 3.9 and 3.2, respectively, which is considered moderate-intensity exercise and could be used to meet daily recommendations for physical activity.

Practical Applications Of Biomechanical Principles In Resistance Training: Neuromuscular Factors And Relationships, Jason Lake, Paul A. Swinton, Justin Keogh

Justin Keogh

This paper is the second in our three part series examining how a variety of biomechanical principles and concepts have direct relevance to the prescription of resistance training for the general and athletic populations as well as for musculoskeletal injury rehabilitation. In this paper, we considered different neuromuscular characteristics of resistance exercise. We started by defining the causes of motion, discussing force and Newton’s second law of linear motion. This led to discussion of impulse, and how its relationship with momentum can be used to study force-time curves recorded from different ground-based resistance exercises. This enables the sports biomechanist to …

Wearable Technology For The Real-Time Analysis Of Sweat During Exercise, D Morris, B Schazmann, Y Wu, C Fay, Stephen T. Beirne, C Slater, King-Tong Lau, Gordon G. Wallace, Dermot Diamond

Gordon Wallace

-Textile based sensors which can be used to measure the chemical composition of bodily fluids represents a major advancement in the area of wearable technology. BIOTEX is an EU funded project aiming to develop such sensors with a particular interest in monitoring perspiration. A textile based fluid handling system has been developed for sample collection and transport. Sodium, conductivity and pH sensors have also been developed. This paper details the integration and testing of these sensors. Results show that the developed system can collect and analyze sweat in real time during exercise and transmit this data wirelessly to a remote …

Sustained And Shorter Bouts Of Physical Activity Are Related To Cardiovascular Health, Nicole Glazer, Asya Lyass, Dale Esliger, Susan Blease, Patty Freedson, Joseph Massaro, Joanne Murabito, Ramachandran Vasan

Patty S. Freedson

Purpose—Whereas greater physical activity (PA) is known to prevent cardiovascular disease (CVD), the relative importance of performing PA in sustained bouts of activity versus shorter bouts of activity on CVD risk is not known. The objective of this study was to investigate the relationship between moderate-to-vigorous physical activity (MVPA), measured in bouts ≥10 minutes and <10 minutes, and CVD risk factors in a well-characterized, community-based sample of white adults. Methods—We conducted a cross-sectional analysis of 2109 Framingham Heart Study Third Generation participants (mean age 47 years, 55% women) who underwent objective assessment of PA by accelerometry over 57 days. Total MVPA, MVPA done in bouts ≥10 minutes (MVPA10+), and MVPA done in bouts <10 minutes (MVPA<10) were calculated. MVPA exposures were related to individual CVD risk factors, including measures of adiposity and blood lipid and glucose levels, using linear and logistic regression. Results—Total MVPA was significantly associated with higher high-density lipoprotein (HDL) levels, and with lower triglycerides, BMI, waist circumference and Framingham risk score (P<0.0001). MVPA<10 showed similar statistically significant associations with these CVD risk factors (P <0.001). Compliance with national guidelines (≥150 minutes of total MVPA) was significantly related to lower BMI, triglycerides, Framingham risk score, waist circumference, higher HDL, and a lower prevalence of obesity and impaired fasting glucose (P < 0.001 for all). Conclusions—Our cross-sectional observations on a large middle-aged community-based sample confirm a positive association of MVPA with a healthier CVD risk factor profile, and indicate that accruing physical activity in bouts <10 minutes may favorably influence cardiometabolic risk. Additional investigations are warranted to confirm our findings.

Introducing The Revised Applied Model Of Deliberate Imagery Use For Sport, Dance, Exercise, And Rehabilitation, Jennifer Cumming, Sarah E. Williams

Jennifer Cumming

This article reviews literature on cognitive and motivational imagery use in the sport, exercise, dance, and rehabilitation domains and outlines a revised applied model of imagery use. The original model by Martin, Moritz, & Hall, 1999 guides practitioners and researchers in determining what cognitive and/or motivational imagery to use in a particular situation for achieving a desired outcome. The revised model proposed builds on the original version by retaining its empiricallysupported “where”, “when”, and “why” components. Incorporating recent advancements in imagery research, the model distinguishes between what is imaged (i.e., the content) from why it is imaged (i.e., the function). …

Motivation, Psychological Distress And Exercise Adherence Following Myocardial Infarction, Angela Ljubic, Frank P. Deane, Robert Zecchin, Richard Denniss

Frank Deane

Fifty patients with myocardial infarction were recruited from a hospital based Cardiac Education and Assessment Program (CEAP) in Sydney, Australia. The Exercise Motivation Inventory-2 (EMI-2) and the Depression, Anxiety and Stress Scale (DASS) were administered prior to commencement in the program and re-administered by telephone interview at 5-month followup. Four exercise adherence measures were completed: attendance, exercise stress test, self-report ratings and a 7-day activity recall interview. There was a 46% adherence rate for MI patients during the hospital based CEAP. Of those individuals who completed CEAP, 91% obtained functional improvement on the exercise stress test. For the 38 patients …

The Effect Of Exercise On The Skeletal Muscle Phospholipidome Of Rats Fed A High-Fat Diet, Todd W. Mitchell, N. Turner, Paul Else, Anthony J. Hulbert, John Hawley, Jong Sam Lee, Clinton Bruce, Stephen J. Blanksby

Stephen Blanksby

The aim of this study was to examine the effect of endurance training on skeletal muscle phospholipid molecular species from high-fat fed rats. Twelve female Sprague- Dawley rats were fed a high-fat diet (78.1% energy). The rats were randomly divided into two groups, a sedentary control group and a trained group (125 min of treadmill running at 8 m/min, 4 days/wk for 4 weeks). Forty-eight hours after their last training bout phospholipids were extracted from the red and white vastus lateralis and analyzed by electrospray-ionization mass spectrometry. Exercise training was associated with significant alterations in the relative abundance of a …

Impact Of Metformin On Peak Aerobic Capacity, Barry Braun, Pamela Eze, Brooke R. Stephens, Todd A. Hagobian, Carrie G. Sharoff, Stuart R. Chipkin, Benjamin Goldstein

Stuart R. Chipkin

Individually, exercise and the drug metformin have been shown to prevent or delay type 2 diabetes. Metformin mildly inhibits complex I of the electron transport system and may impact aerobic capacity in people exercising while taking metformin. The purpose of the study was to evaluate the effects of metformin on maximal aerobic capacity in healthy individuals without mitochondrial dysfunction. Seventeen healthy, normal-weight men (n=11) and women (n=6) participated in a double-blind, placebo-controlled, cross-over design. Peak aerobic capacity was measured twice using a continuous, incrementally graded protocol; once after 7-9 d of metformin (final dose=2000 mg/d) and once with placebo, with …

Physical Activity And Sedentary Activity Patterns Among Children And Adolescents: A Latent Class Analysis Approach, Carrie Heitzler, Leslie Lytle, Darin Erickson, John Sirard, Daheia Barr-Anderson, Marry Story

John Sirard

Background—While much is known about the overall levels of physical activity and sedentary activity among youth, few studies have attempted to define clusters of such behaviors. The purpose of this study was to identify and describe unique classes of youth based on their participation in a variety of physical activity and sedentary behaviors. Methods—Latent class analysis was used to characterize segments of youth based on patterns of self-reported and accelerometer-measured participation in 12 behaviors. Children and adolescents (N=720) from 6th–11th grade were included in the analysis. Differences in class membership were examined using multinomial logistic regression. Results—Three distinct classes emerged …

Can Self-Esteem Protect Against The Deleterious Consequences Of Self-Objectification For Mood And Body Satisfaction In Physically Active Female University Students?, Cecilie Thøgersen-Ntoumani, Nikos Ntoumanis, Jennifer Cumming, Kimberley J. Bartholomew, Gemma Pearce

Jennifer Cumming

Using objectification theory (Fredrickson & Roberts, 1997), this study tested the interaction between self-objectification, appearance evaluation, and self-esteem in predicting body satisfaction and mood states. Participants (N = 93) were physically active female university students. State self-objectification was manipulated by participants wearing tight revealing exercise attire (experimental condition) or baggy exercise clothes (control condition). Significant interactions emerged predicting depression, anger, fatness, and satisfaction with body shape and size. For participants in the self-objectification condition who had low (as opposed to high) appearance evaluation, low self-esteem was associated with high depression, anger, and fatness and low satisfaction with body shape and …

Feasibility And Efficacy Of A Physical Activity Intervention Among Pregnant Women: The Behaviors Affecting Baby And You (B.A.B.Y.) Study, Lisa Chasan-Taber, Marushka Silveira, Bess Marcus, Barry Braun, Edward Stanek, Glenn Markenson

Barry Braun

Background: Physical activity during pregnancy is associated with reduced risk of adverse maternal and fetal outcomes. However, the majority of pregnant women are inactive and interventions designed to increase exercise during pregnancy are sparse. We evaluated the feasibility and preliminary efficacy of an exercise intervention among a diverse sample of pregnant women. Methods: The B.A.B.Y. (Behaviors Affecting Baby and You) Study is conducted at a large tertiary care facility in Western Massachusetts. We randomized 110 prenatal care patients (60% Hispanic) to an individually tailored 12-week exercise intervention arm (n = 58) or to a health and wellness control arm (n …

Research Review: Fun Or Fitness?, Mike Climstein

Mike Climstein

No abstract provided.

An Intervention To Prevent Symptoms Associated With Hepatitis C: A Pilot Study, Donna M. Zucker

Donna M. Zucker

The objectives of this study were to (a) pilot test instruments measuring fatigue and quality of life (QOL); (b) pilot test an exercise intervention; and (c) estimate the effect size of this intervention relative to completion of combination therapy, fatigue, QOL, and walking distance in 20 patients with chronic hepatitis C about to begin interferon alpha and ribavirin treatment. Alpha reliabilities for both the Schwartz Cancer Fatigue Scale and Hepatitis Quality of Life Questionnaire were moderately high. Power analyses of all outcome measures indicated a small effect size and sample size estimate of 30–40 per group to achieve power of …

A Prospective Cohort Study Of Exercise And The Incidence Of Type 2 Diabetes In Impaired Fasting Glucose Group, Hong-Dae Um, Duck-Chul Lee, Sang-Yi Lee, Yeon-Soo Kim

Duck-Chul Lee

Objectives : To determine the relationship between exercise and the incidence of type 2 diabetes in an impaired fasting glucose group. Methods : This prospective cohort study was conducted in 19,440 men and 4,297 women, aged 30-69 years, with impaired fasting glucose at baseline who had undergone biennial medical evaluation through the National Health Insurance Corporation from 2000 to 2004. Impaired fasting glucose was defined as fasting glucose of 100 to 125 mg/dl and the subjects were divided into 3 groups depending on weekly exercise frequency. Multivariate logistic regression analysis was used to evaluate the association between the baseline exercise …