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Full-Text Articles in Life Sciences
Design And Analysis Of Biological Assays Of Mixtures, Nancy Ferry, Bruce H. Stanley, Gregory Armel
Design And Analysis Of Biological Assays Of Mixtures, Nancy Ferry, Bruce H. Stanley, Gregory Armel
Conference on Applied Statistics in Agriculture
The simultaneous activity of multiple stimuli can be difficult to analyze, particularly on biological systems. However, these analyses are becoming increasingly important in drug or pesticide formulation for efficacy. This article will review techniques for the design and analysis of bioassays of mixtures. The two major techniques that will be reviewed are based upon the concepts of response and potency. Particular emphasis will be placed upon measuring levels of synergy, i.e., when the activity is greater than the sum of its parts, and antagonism, i.e., when the activity is less than would be expected. Theoretical examples will be given to …
Modeling And Design To Detect Interaction Of Insecticides, Herbicides And Other Similar Compounds, Timothy E. O'Brien
Modeling And Design To Detect Interaction Of Insecticides, Herbicides And Other Similar Compounds, Timothy E. O'Brien
Conference on Applied Statistics in Agriculture
This paper discusses model and experimental design aspects of agricultural studies aimed at discerning antagonism or synergy between two or more insecticides, herbicides, or other similar compounds. The developed methods involve a broad class of generalised nonlinear models, which are easily fitted to data using popular statistical packages such as the NLMIXED procedure in SAS® software. Sample computer code is given in the Appendix.