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Full-Text Articles in Life Sciences
Migration Frustrations Of Mir-146a Regulation, Emma Baccus, Victoria Gahman, Hannah Phillips, Shannon Rappaport, Alyssa Reiter, Kaleb M. Pauley
Migration Frustrations Of Mir-146a Regulation, Emma Baccus, Victoria Gahman, Hannah Phillips, Shannon Rappaport, Alyssa Reiter, Kaleb M. Pauley
The Research and Scholarship Symposium (2013-2019)
The autoimmune disease, Sjögren’s Syndrome (SS), causes the degradation of salivary and lacrimal glands due to an influx of immune cells. In previous studies, a significant increase in miR-146a was observed in the peripheral blood mononuclear cells of SS patients. Since immune cell infiltration is critical in SS pathogenesis, the following research examines the effect of miR-146a on cell migration. We hypothesize that transfecting THP-1 human monocytes with synthetic miR-146a will downregulate migration of the monocytes based on other studies stating that miR-146a downregulates migration in vivo. In order to execute our experiment, we transfected THP-1 cells with synthetic miR-146a …
Effect Of Metformin On Mir-146a Expression, S. Jackson Grout, Bryce C. Macturk, Amanda D. Sims, Kaleb M. Pauley
Effect Of Metformin On Mir-146a Expression, S. Jackson Grout, Bryce C. Macturk, Amanda D. Sims, Kaleb M. Pauley
The Research and Scholarship Symposium (2013-2019)
Sjögren’s Syndrome (SjS) is an autoimmune disorder that affects secretory glands in the human body, restricting their function and causing extreme dryness in areas like the mouth and eyes. miR-146a is an anti-inflammatory microRNA that targets the NFκB activation pathway. Previous studies have shown that SjS patients have increased miR-146a expression, despite having high levels of inflammation. The objective of this study was to investigate whether metformin, a diabetes drug with a wide variety of effects and potential functions, reduces levels of miR-146a expression. Metformin is known to reduce inflammation by inhibiting the activation of NFκB. THP-1 human monocytes were …
Mir-146a Upregulation Of Phagocytosis In Human Macrophages, Ryan Marquardt, Daniel J. Stank, Kaleb M. Pauley
Mir-146a Upregulation Of Phagocytosis In Human Macrophages, Ryan Marquardt, Daniel J. Stank, Kaleb M. Pauley
The Research and Scholarship Symposium (2013-2019)
Sjögrens Syndrome (SjS) is an autoimmune disease that attacks exocrine glands such as salivary and lacrimal glands resulting in severe dryness of the mouth and eyes. Previous studies have linked increased microRNA-146a (miR-146a) expression in peripheral blood mononuclear cells in SjS patients compared to healthy controls. MicroRNAs (miRNAs), small non-coding RNA molecules that post-transcriptionally regulate gene expression, are known to play key regulatory roles in immune responses and have been implicated in a growing number of autoimmune disorders. Further investigation into the role of increased miR-146a expression in SjS revealed links to several immune functions including phagocytosis.Our goal was to …